Neuroscience
Kranick SM, & Duda JE. Olfactory dysfunction in Parkinson's disease. Neurosignals. 2008; 16(1): 35-40.
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Prior to the onset of the cardinal motor features of idiopathic Parkinson's disease (PD), other manifestations of neurodegeneration such as olfactory dysfunction are often apparent. Characterizing these potential biomarkers of preclinical PD is particularly important in identifying individuals who will go on to develop disabling symptoms, and thus be good candidates for new neuroprotective strategies. As shown by the Braak neuropathologic staging of PD, the olfactory system is among the first neuronal populations to display Lewy body pathology. Clinically, loss of smell can be easily tested in the office using several validated techniques and is often helpful to the physician in distinguishing idiopathic PD from other forms of parkinsonism. Recent findings have indicated that a decline in olfaction may be observed in selected at-risk patients, which has significant implications for identifying potential study populations. Ongoing studies of olfactory dysfunction may also reveal potential for use as a medication-independent biomarker of disease progression in addition to use as a biomarker for the diagnosis of PD.
Publication Types: Review
PMID: 18097158 [PubMed - indexed for MEDLINE]
- Neuropsychology Abstract Of The Day: Parkinson's And Anosmia
Odor identification deficits identify Parkinson's disease patients with poor cognitive performance Movement Disorders. 2011 Sep;26(11):2045-50 Damholdt MF, Borghammer P, Larsen L, Ostergaard K Abstract Olfactory dysfunction is a prodromal and prevalent...
- Neuropsychology Abstract Of The Day: Olfaction And Neurodegenerative Disease
Just noticeable difference in olfaction: A discriminative tool between healthy elderly and patients with cognitive disorders associated with dementia Rhinology. 2011 15 1; 49(5): 513-518. Chopard G, Galmiche J, Jacquot L, Brand G Abstract Olfactory dysfunction...
- Neuropsychology Abstract Of The Day: Parkinson's Disease And Olfaction
Landis BN & Burkhard PR. Phantosmias and Parkinson disease. Archives of Neurology. 2008 Sep; 65(9): 1237-1239. BACKGROUND: Impaired olfaction is a common, nonmotor manifestation of Parkinson disease (PD). However, to our knowledge, qualitative olfactory...
- Neuropsychology Abstract Of The Day: Olfactory Functioning And Mild Cognitive Impairment (mci)
Djordjevic J, Jones-Gotman M, De Sousa K, & Chertkow H. (2007). Olfaction in patients with mild cognitive impairment and Alzheimer's disease. Neurobiology and Aging [epub ahead of print.] Montreal Neurological Institute, 3801 University Street, Department...
- Abstract Of The Day: Smell Identification And Anosmia Screening
Jackman AH & Doty RL. Utility of a three-item smell identification test in detecting olfactory dysfunction. Laryngoscope. 2005 Dec; 115(12): 2209-2212. From the Smell and Taste Center, Department of Otorhinolaryngology-Head and Neck Surgery, Hospital...
Neuroscience
Neuropsychology Abstract of the Day: Parkinson's Disease and Olfaction
Kranick SM, & Duda JE. Olfactory dysfunction in Parkinson's disease. Neurosignals. 2008; 16(1): 35-40.
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Prior to the onset of the cardinal motor features of idiopathic Parkinson's disease (PD), other manifestations of neurodegeneration such as olfactory dysfunction are often apparent. Characterizing these potential biomarkers of preclinical PD is particularly important in identifying individuals who will go on to develop disabling symptoms, and thus be good candidates for new neuroprotective strategies. As shown by the Braak neuropathologic staging of PD, the olfactory system is among the first neuronal populations to display Lewy body pathology. Clinically, loss of smell can be easily tested in the office using several validated techniques and is often helpful to the physician in distinguishing idiopathic PD from other forms of parkinsonism. Recent findings have indicated that a decline in olfaction may be observed in selected at-risk patients, which has significant implications for identifying potential study populations. Ongoing studies of olfactory dysfunction may also reveal potential for use as a medication-independent biomarker of disease progression in addition to use as a biomarker for the diagnosis of PD.
Publication Types: Review
PMID: 18097158 [PubMed - indexed for MEDLINE]
- Neuropsychology Abstract Of The Day: Parkinson's And Anosmia
Odor identification deficits identify Parkinson's disease patients with poor cognitive performance Movement Disorders. 2011 Sep;26(11):2045-50 Damholdt MF, Borghammer P, Larsen L, Ostergaard K Abstract Olfactory dysfunction is a prodromal and prevalent...
- Neuropsychology Abstract Of The Day: Olfaction And Neurodegenerative Disease
Just noticeable difference in olfaction: A discriminative tool between healthy elderly and patients with cognitive disorders associated with dementia Rhinology. 2011 15 1; 49(5): 513-518. Chopard G, Galmiche J, Jacquot L, Brand G Abstract Olfactory dysfunction...
- Neuropsychology Abstract Of The Day: Parkinson's Disease And Olfaction
Landis BN & Burkhard PR. Phantosmias and Parkinson disease. Archives of Neurology. 2008 Sep; 65(9): 1237-1239. BACKGROUND: Impaired olfaction is a common, nonmotor manifestation of Parkinson disease (PD). However, to our knowledge, qualitative olfactory...
- Neuropsychology Abstract Of The Day: Olfactory Functioning And Mild Cognitive Impairment (mci)
Djordjevic J, Jones-Gotman M, De Sousa K, & Chertkow H. (2007). Olfaction in patients with mild cognitive impairment and Alzheimer's disease. Neurobiology and Aging [epub ahead of print.] Montreal Neurological Institute, 3801 University Street, Department...
- Abstract Of The Day: Smell Identification And Anosmia Screening
Jackman AH & Doty RL. Utility of a three-item smell identification test in detecting olfactory dysfunction. Laryngoscope. 2005 Dec; 115(12): 2209-2212. From the Smell and Taste Center, Department of Otorhinolaryngology-Head and Neck Surgery, Hospital...