Neuroscience
Just noticeable difference in olfaction: A discriminative tool between healthy elderly and patients with cognitive disorders associated with dementia
Rhinology. 2011 15 1; 49(5): 513-518.
Chopard G, Galmiche J, Jacquot L, Brand G
Abstract
Olfactory dysfunction appears to be one of the earliest signs of several age-related neurodegenerative disorders, including Alzheimer`s disease (AD) or Parkinson`s disease (PD). To rate performance and olfactory deficits in patients with cognitive disorders, various olfactory tasks have been used such as odor detection, discrimination, recognition memory, identification and naming but no study has been focused on just noticeable difference (JND), a sensitive tool of detection. The aim of this study was to investigate and compare variations in JNDs in healthy elderly and in patients with cognitive disorders associated with dementia. The results showed significantly higher olfactory JNDs in a population with cognitive disorders associated with dementia - i.e. a lower olfactory detection performance - compared to a control population paired in age, gender and education level. Additionally, the findings of the present study showed strong correlations between cognitive performances and JND scores in the control population contrary to the patient population. These findings are discussed in relation to the relevance of using olfactory JNDs in the diagnosis of dementias.
PMID: 22125780 [PubMed - as supplied by publisher]
Anthony Risser
BrainBlog
http://neuropsychological.blogspot.com
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- Neuropsychology Abstract Of The Day: Parkinson's Disease And Olfaction
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Neuroscience
Neuropsychology Abstract of the Day: Olfaction and Neurodegenerative Disease
Just noticeable difference in olfaction: A discriminative tool between healthy elderly and patients with cognitive disorders associated with dementia
Rhinology. 2011 15 1; 49(5): 513-518.
Chopard G, Galmiche J, Jacquot L, Brand G
Abstract
Olfactory dysfunction appears to be one of the earliest signs of several age-related neurodegenerative disorders, including Alzheimer`s disease (AD) or Parkinson`s disease (PD). To rate performance and olfactory deficits in patients with cognitive disorders, various olfactory tasks have been used such as odor detection, discrimination, recognition memory, identification and naming but no study has been focused on just noticeable difference (JND), a sensitive tool of detection. The aim of this study was to investigate and compare variations in JNDs in healthy elderly and in patients with cognitive disorders associated with dementia. The results showed significantly higher olfactory JNDs in a population with cognitive disorders associated with dementia - i.e. a lower olfactory detection performance - compared to a control population paired in age, gender and education level. Additionally, the findings of the present study showed strong correlations between cognitive performances and JND scores in the control population contrary to the patient population. These findings are discussed in relation to the relevance of using olfactory JNDs in the diagnosis of dementias.
PMID: 22125780 [PubMed - as supplied by publisher]
Anthony Risser
BrainBlog
http://neuropsychological.blogspot.com
- Neuropsychology Abstract Of The Day: Parkinson's And Anosmia
Odor identification deficits identify Parkinson's disease patients with poor cognitive performance Movement Disorders. 2011 Sep;26(11):2045-50 Damholdt MF, Borghammer P, Larsen L, Ostergaard K Abstract Olfactory dysfunction is a prodromal and prevalent...
- Neuropsychology Abstract Of The Day: Parkinson's Disease And Olfaction
Landis BN & Burkhard PR. Phantosmias and Parkinson disease. Archives of Neurology. 2008 Sep; 65(9): 1237-1239. BACKGROUND: Impaired olfaction is a common, nonmotor manifestation of Parkinson disease (PD). However, to our knowledge, qualitative olfactory...
- Neuropsychology Abstract Of The Day: Parkinson's Disease And Olfaction
Kranick SM, & Duda JE. Olfactory dysfunction in Parkinson's disease. Neurosignals. 2008; 16(1): 35-40. Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Prior to the onset of the cardinal motor features...
- Neuropsychology Abstract Of The Day: Parkinson's Disease
Pagonabarraga J, Kulisevsky J, Llebaria G, García-Sánchez C, Pascual-Sedano B, & Gironell A. Parkinson's disease-cognitive rating scale: A new cognitive scale specific for Parkinson's disease. Movement Disorders. 2008 Mar 31 [Epub ahead of print]....
- Neuropsychology Abstract Of The Day: Olfaction And Dementia
Hubbard PS, Esiri MM, Reading M, McShane R, & Nagy Z. Alpha-synuclein pathology in the olfactory pathways of dementia patients. Journal of Anatomy. 2007 Jun 6; [Epub ahead of print] Division of Neuroscience, The Medical School, University of Birmingham,...