Neuroscience
Brain regions with mirror properties: A meta-analysis of 125 human fMRI studies
Neuroscience Biobehavioral Rev. 2011 Jul 18. [Epub ahead of print]
Molenberghs P, Cunnington R, Mattingley JB.
Abstract
Mirror neurons in macaque area F5 fire when an animal performs an action, such as a mouth or limb movement, and also when the animal passively observes an identical or similar action performed by another individual. Brain-imaging studies in humans conducted over the last 20 years have repeatedly attempted to reveal analogous brain regions with mirror properties in humans, with broad and often speculative claims about their functional significance across a range of cognitive domains, from language to social cognition. Despite such concerted efforts, the likely neural substrates of these mirror regions have remained controversial, and indeed the very existence of a distinct subcategory of human neurons with mirroring properties has been questioned. Here we used activation likelihood estimation (ALE), to provide a quantitative index of the consistency of patterns of fMRI activity measured in human studies of action observation and action execution. From an initial sample of more than 300 published works, data from 125 papers met our strict inclusion and exclusion criteria. The analysis revealed 14 separate clusters in which activation has been consistently attributed to brain regions with mirror properties, encompassing 9 different Brodmann areas. These clusters were located in areas purported to show mirroring properties in the macaque, such as the inferior parietal lobule, inferior frontal gyrus and the adjacent ventral premotor cortex, but surprisingly also in regions such as the primary visual cortex, cerebellum and parts of the limbic system. Our findings suggest a core network of human brain regions that possess mirror properties associated with action observation and execution, with additional areas recruited during tasks that engage non-motor functions, such as auditory, somatosensory and affective components.
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
PMID: 21782846 [PubMed - as supplied by publisher]
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Neuroscience
Neuropsychology Abstract of the Day: Mirror Neurons
Brain regions with mirror properties: A meta-analysis of 125 human fMRI studies
Neuroscience Biobehavioral Rev. 2011 Jul 18. [Epub ahead of print]
Molenberghs P, Cunnington R, Mattingley JB.
Abstract
Mirror neurons in macaque area F5 fire when an animal performs an action, such as a mouth or limb movement, and also when the animal passively observes an identical or similar action performed by another individual. Brain-imaging studies in humans conducted over the last 20 years have repeatedly attempted to reveal analogous brain regions with mirror properties in humans, with broad and often speculative claims about their functional significance across a range of cognitive domains, from language to social cognition. Despite such concerted efforts, the likely neural substrates of these mirror regions have remained controversial, and indeed the very existence of a distinct subcategory of human neurons with mirroring properties has been questioned. Here we used activation likelihood estimation (ALE), to provide a quantitative index of the consistency of patterns of fMRI activity measured in human studies of action observation and action execution. From an initial sample of more than 300 published works, data from 125 papers met our strict inclusion and exclusion criteria. The analysis revealed 14 separate clusters in which activation has been consistently attributed to brain regions with mirror properties, encompassing 9 different Brodmann areas. These clusters were located in areas purported to show mirroring properties in the macaque, such as the inferior parietal lobule, inferior frontal gyrus and the adjacent ventral premotor cortex, but surprisingly also in regions such as the primary visual cortex, cerebellum and parts of the limbic system. Our findings suggest a core network of human brain regions that possess mirror properties associated with action observation and execution, with additional areas recruited during tasks that engage non-motor functions, such as auditory, somatosensory and affective components.
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
PMID: 21782846 [PubMed - as supplied by publisher]
- Is This The First Ever Direct Evidence For Human Mirror Neurons?
Mirror neurons are one of the most hyped concepts in psychology and neurocience. V.S. Ramachandran famously wrote that they will 'do for psychology what DNA did for biology'. Although recordings from single cells in the brains of monkeys have...
- Mirror Neurons Join Marilyn Monroe Neurons And Halle Berry Neurons In The Human Hippocampus
Move over, Marilyn Monroe neurons and Halle Berry neurons... The cellular media darlings of action observation and action execution would like to join you in the human hippocampus and surrounding medial temporal lobe (MTL) areas critical for memory....
- Mirror Neuron Death March
Above image: Jim Peters almost wins the marathon Vancouver, 7 August 1954, with mirror neurons by Rizzolatti & Craighero (2004). Greg Hickok at Talking Brains has a series of posts dismantling the mirror neuron theory of action understanding. Actually,...
- Mirror Neurons Control Hard-ons?
from MR BEAN IN TOILET Everyone knows that mirror neurons control the universe. Now, a study by Mourus and colleagues supposedly tells us that mirror neurons control the most important thing in the universe! Mirror neurons control erection response to...
- Spindle Neurons: The Next New Thing?
In a neuroanatomical tour de force, Nimchinsky and colleagues (1999) obtained access to samples of the anterior cingulate cortex (and other cortical regions) from 28 different primate species, from prosimians to anthropoids to great apes to humans. They...