Neuroscience
There have been a number of excellent papers published over the past month in a number of different journals on the topic of Mild Cognitive Impairment (MCI). Looking forward to reading this new paper:
An exploration of subgroups of mild cognitive impairment based on cognitive, neuropsychiatric and functional features: analysis of data from the national Alzheimer's coordinating center
American Journal of Geriatric Psychiatry. 2011 Nov; 19(11): 940-950.
Hanfelt JJ, Wuu J, Sollinger AB, Greenaway MC, Lah JJ, Levey AI, Goldstein FC
Abstract
OBJECTIVES: : To empirically expand the existing subtypes of mild cognitive impairment (MCI) by incorporating information on neuropsychiatric and functional features, and to assess whether cerebrovascular disease (CVD) risk factors are associated with any of these subgroups.
DESIGN: : Latent class analysis using 1,655 patients with MCI.
SETTING: : Participants in the Uniform Data Set (UDS) from 29 National Institutes of Health-supported Alzheimer's Disease Centers.
PARTICIPANTS: : Patients with a consensus diagnosis of MCI from each center and with a Mini-Mental State Examination score of 22 or greater.
MEASUREMENTS: : UDS cognitive battery, Neuropsychiatric Inventory Questionnaire, and Functional Assessment Questionnaire administered at initial visit.
RESULTS: : Seven empirically based subgroups of MCI were identified: 1) minimally impaired (relative frequency, 12%); 2) amnestic only (16%); 3) amnestic with functional and neuropsychiatric features (16%); 4) amnestic multidomain (12%); 5) amnestic multidomain with functional and neuropsychiatric features (12%); 6) functional and neuropsychiatric features (15%); and 7) executive function and language impairments (18%). Two of these subgroups with functional and neuropsychiatric features were at least 3.8 times more likely than the minimally impaired subgroup to have a Rosen-Hachinski score of 4 or greater, an indicator of probable CVD.
CONCLUSIONS: : Findings suggest that there are several distinct phenotypes of MCI characterized by prominent cognitive features, prominent functional features, and neuropsychiatric features or a combination of all three. Subgroups with functional and neuropsychiatric features are significantly more likely to have CVD, which suggests that there may be distinct differences in disease etiology from the other phenotypes.
PMID: 22024618 [PubMed - in process]
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Cognitive and behavioural predictors of survival in Alzheimer disease: Results from a sample of treated patients in a tertiary-referral memory clinic Int J Geriatr Psychiatry. 2011 Sep 29; Russ TC, Batty GD, Starr JM Abstract OBJECTIVE: This study examined...
- Neuropsychology Abstract Of The Day: Aging And Mci Screening
Today's recommended read deals with an important neuropsychological assessment issue in the domain of aging and the potential to identify the presence of cognitive problems that might (emphasis on "might" - such findings in a screen are not definitive)...
- Neuropsychology Abstract Of The Day: Donepezil, Mci, And Ad
Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL & Alzheimer's Disease Cooperative Study Group. (2009) Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology, 72(24):, 2115-2121. Departments of Neurology,...
- Neuropsychology Abstract Of The Day: Mild Cognitive Impairment (mci)
Fleisher AS, Sun S, Taylor C, Ward CP, Gamst AC, Petersen RC, Jack CR, Aisen PS, & Thal LJ. Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment. Neurology. 2008 Jan 15; 70(3): 191-199. OBJECTIVE: To compare volumetric...
- Abstract Of The Day: Neuropsychology Of Mild Cognitive Impairment (mci)
Lopez OL, Becker JT, Jagust W, Fitzpatrick A, Carlson M, T DU, Breitner J, Lyketsos C, Jones B, Kawas C, & Kuller LH. Neuropsychological characteristics of mild cognitive impairment subgroups. Journal of Neurology Neurosurgery and Psychiatry. 2005 Aug...
Neuroscience
Neuropsychology Abstract of the Day: Mild Cognitive Impairment
There have been a number of excellent papers published over the past month in a number of different journals on the topic of Mild Cognitive Impairment (MCI). Looking forward to reading this new paper:
An exploration of subgroups of mild cognitive impairment based on cognitive, neuropsychiatric and functional features: analysis of data from the national Alzheimer's coordinating center
American Journal of Geriatric Psychiatry. 2011 Nov; 19(11): 940-950.
Hanfelt JJ, Wuu J, Sollinger AB, Greenaway MC, Lah JJ, Levey AI, Goldstein FC
Abstract
OBJECTIVES: : To empirically expand the existing subtypes of mild cognitive impairment (MCI) by incorporating information on neuropsychiatric and functional features, and to assess whether cerebrovascular disease (CVD) risk factors are associated with any of these subgroups.
DESIGN: : Latent class analysis using 1,655 patients with MCI.
SETTING: : Participants in the Uniform Data Set (UDS) from 29 National Institutes of Health-supported Alzheimer's Disease Centers.
PARTICIPANTS: : Patients with a consensus diagnosis of MCI from each center and with a Mini-Mental State Examination score of 22 or greater.
MEASUREMENTS: : UDS cognitive battery, Neuropsychiatric Inventory Questionnaire, and Functional Assessment Questionnaire administered at initial visit.
RESULTS: : Seven empirically based subgroups of MCI were identified: 1) minimally impaired (relative frequency, 12%); 2) amnestic only (16%); 3) amnestic with functional and neuropsychiatric features (16%); 4) amnestic multidomain (12%); 5) amnestic multidomain with functional and neuropsychiatric features (12%); 6) functional and neuropsychiatric features (15%); and 7) executive function and language impairments (18%). Two of these subgroups with functional and neuropsychiatric features were at least 3.8 times more likely than the minimally impaired subgroup to have a Rosen-Hachinski score of 4 or greater, an indicator of probable CVD.
CONCLUSIONS: : Findings suggest that there are several distinct phenotypes of MCI characterized by prominent cognitive features, prominent functional features, and neuropsychiatric features or a combination of all three. Subgroups with functional and neuropsychiatric features are significantly more likely to have CVD, which suggests that there may be distinct differences in disease etiology from the other phenotypes.
PMID: 22024618 [PubMed - in process]
- Neuropsychology Abstract Of The Day: "cognitive And Behavioural Predictors Of Survival In Alzheimer Disease"
Cognitive and behavioural predictors of survival in Alzheimer disease: Results from a sample of treated patients in a tertiary-referral memory clinic Int J Geriatr Psychiatry. 2011 Sep 29; Russ TC, Batty GD, Starr JM Abstract OBJECTIVE: This study examined...
- Neuropsychology Abstract Of The Day: Aging And Mci Screening
Today's recommended read deals with an important neuropsychological assessment issue in the domain of aging and the potential to identify the presence of cognitive problems that might (emphasis on "might" - such findings in a screen are not definitive)...
- Neuropsychology Abstract Of The Day: Donepezil, Mci, And Ad
Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL & Alzheimer's Disease Cooperative Study Group. (2009) Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology, 72(24):, 2115-2121. Departments of Neurology,...
- Neuropsychology Abstract Of The Day: Mild Cognitive Impairment (mci)
Fleisher AS, Sun S, Taylor C, Ward CP, Gamst AC, Petersen RC, Jack CR, Aisen PS, & Thal LJ. Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment. Neurology. 2008 Jan 15; 70(3): 191-199. OBJECTIVE: To compare volumetric...
- Abstract Of The Day: Neuropsychology Of Mild Cognitive Impairment (mci)
Lopez OL, Becker JT, Jagust W, Fitzpatrick A, Carlson M, T DU, Breitner J, Lyketsos C, Jones B, Kawas C, & Kuller LH. Neuropsychological characteristics of mild cognitive impairment subgroups. Journal of Neurology Neurosurgery and Psychiatry. 2005 Aug...