Neuroscience
Lopez OL, Becker JT, Jagust W, Fitzpatrick A, Carlson M, T DU, Breitner J, Lyketsos C, Jones B, Kawas C, & Kuller LH.
Neuropsychological characteristics of mild cognitive impairment subgroups. Journal of Neurology Neurosurgery and Psychiatry. 2005 Aug 15; [Epub ahead of print]
University of Pittsburgh, U.S.A., United States.
OBJECTIVES: To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) Cognition Study. METHODS: MCI was classified as follows: MCI Amnestic-type (MCI-AT): These were patients with documented memory deficits, with otherwise normal cognitive functions. MCI-Multiple cognitive deficits-type (MCDT): These patients had impairment in at least one cognitive domain (not including memory), or one abnormal test in at least two other domains, but who have not crossed the threshold for dementia. The MCI subjects did not have systemic, neurological, or psychiatric disorders that may have affected cognition. This study was conducted only in the CHS cases from Pittsburgh. RESULTS: MCI-AT (n=10) had worse verbal and non-verbal memory performance than MCI-MCDT (n=28), and normal controls (n=374). By contrast, MCI-MCDT had worse language, psychomotor speed, fine motor control, and visuoconstructional function performance than MCI-AT and normal controls. In addition, MCI-MCDT subjects had memory deficits, although they were less pronounced than those of the MCI-AT. Of the MCI-MCDT cases, 22 (78.5%) had memory deficits, and 6 (21.5%) did not. The MCI-MCDT with memory disorders had more language deficits than the MCI-MCDT without memory disorders. By contrast the MCI-MCDT without memory deficits had more fine motor control deficits than the MCI-MCDT with memory deficits. CONCLUSIONS: The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups, did not reflect the true prevalence of MCI in a population, since 16% of all MCI cases, and 21.5% of the MCI-MCDT cases did not have memory impairments. The study of idiopathic amnestic and non-anmestic forms of MCI is essential for our understanding the etiology of MCI.
PMID: 16103044 [PubMed - as supplied by publisher]
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Anthony H. Risser | neuroscience | neuropsychology | brain
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- Neuropsychology Abstract Of The Day: Olfactory Functioning And Mild Cognitive Impairment (mci)
Djordjevic J, Jones-Gotman M, De Sousa K, & Chertkow H. (2007). Olfaction in patients with mild cognitive impairment and Alzheimer's disease. Neurobiology and Aging [epub ahead of print.] Montreal Neurological Institute, 3801 University Street, Department...
Neuroscience
Abstract of the Day: Neuropsychology of Mild Cognitive Impairment (MCI)
Lopez OL, Becker JT, Jagust W, Fitzpatrick A, Carlson M, T DU, Breitner J, Lyketsos C, Jones B, Kawas C, & Kuller LH.
Neuropsychological characteristics of mild cognitive impairment subgroups. Journal of Neurology Neurosurgery and Psychiatry. 2005 Aug 15; [Epub ahead of print]
University of Pittsburgh, U.S.A., United States.
OBJECTIVES: To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) Cognition Study. METHODS: MCI was classified as follows: MCI Amnestic-type (MCI-AT): These were patients with documented memory deficits, with otherwise normal cognitive functions. MCI-Multiple cognitive deficits-type (MCDT): These patients had impairment in at least one cognitive domain (not including memory), or one abnormal test in at least two other domains, but who have not crossed the threshold for dementia. The MCI subjects did not have systemic, neurological, or psychiatric disorders that may have affected cognition. This study was conducted only in the CHS cases from Pittsburgh. RESULTS: MCI-AT (n=10) had worse verbal and non-verbal memory performance than MCI-MCDT (n=28), and normal controls (n=374). By contrast, MCI-MCDT had worse language, psychomotor speed, fine motor control, and visuoconstructional function performance than MCI-AT and normal controls. In addition, MCI-MCDT subjects had memory deficits, although they were less pronounced than those of the MCI-AT. Of the MCI-MCDT cases, 22 (78.5%) had memory deficits, and 6 (21.5%) did not. The MCI-MCDT with memory disorders had more language deficits than the MCI-MCDT without memory disorders. By contrast the MCI-MCDT without memory deficits had more fine motor control deficits than the MCI-MCDT with memory deficits. CONCLUSIONS: The most frequent form of MCI was the MCI-MCDT with memory deficits. However, the identification of memory impaired MCI groups, did not reflect the true prevalence of MCI in a population, since 16% of all MCI cases, and 21.5% of the MCI-MCDT cases did not have memory impairments. The study of idiopathic amnestic and non-anmestic forms of MCI is essential for our understanding the etiology of MCI.
PMID: 16103044 [PubMed - as supplied by publisher]
-
Anthony H. Risser | neuroscience | neuropsychology | brain
- Neuropsychology Abstract Of The Day: Prospective Memory
Remember to Buy Milk on the Way Home! A Meta-analytic Review of Prospective Memory in Mild Cognitive Impairment and Dementia. Journal of the International Neuropsychological Society. 2012 May 18;:1-11 Authors: van den Berg E, Kant N, Postma A Abstract...
- Neuropsychology Abstract Of The Day: Parkinson's And Anosmia
Odor identification deficits identify Parkinson's disease patients with poor cognitive performance Movement Disorders. 2011 Sep;26(11):2045-50 Damholdt MF, Borghammer P, Larsen L, Ostergaard K Abstract Olfactory dysfunction is a prodromal and prevalent...
- Neuropsychology Abstract Of The Day: Cortical Neuroanatomy Of Neuropsychological Deficits
The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: A surface-based morphometric analysis Neuropsychologia. 2011 Oct 15; Ahn HJ, Seo SW, Chin J, Suh MK, Lee BH, Kim ST, Im K, Lee JM, Lee JH,...
- Neuropsychology Abstract Of The Day: Chronic Congestive Heart Failure And Neuropsychological Function
Vogels RL, Oosterman JM, van Harten B, Scheltens P, van der Flier WM, Schroeder-Tanka JM, & Weinstein HC. Profile of Cognitive Impairment in Chronic Heart Failure. Journal of the American Geriatrics Society. 2007 Aug 28; [Epub ahead of print]. Department...
- Neuropsychology Abstract Of The Day: Olfactory Functioning And Mild Cognitive Impairment (mci)
Djordjevic J, Jones-Gotman M, De Sousa K, & Chertkow H. (2007). Olfaction in patients with mild cognitive impairment and Alzheimer's disease. Neurobiology and Aging [epub ahead of print.] Montreal Neurological Institute, 3801 University Street, Department...