Neuroscience
Cognitive and behavioural predictors of survival in Alzheimer disease: Results from a sample of treated patients in a tertiary-referral memory clinic
Int J Geriatr Psychiatry. 2011 Sep 29;
Russ TC, Batty GD, Starr JM
Abstract
OBJECTIVE: This study examined the influence of cognitive and non-cognitive factors at the time of diagnosis on the survival of patients with treated probable Alzheimer Disease (AD). METHODS: Consecutive patients seen at a regional, tertiary-referral clinic completed a battery of cognitive tests and assessments of activities of daily living and neuropsychiatric symptoms. These clinic data were linked with death certificate data for all individuals and survival from diagnosis was calculated. Cox regression models were constructed using the baseline covariates. RESULTS: The sample comprised 653 patients (459 women), mean age 77.1 years (SD 7.6, range 48-94 years), diagnosed with probable AD and treated with a cholinesterase inhibitor. In the survival analysis, age was a consistently significant predictor of survival with a gender-adjusted hazard ratio of 1.35 (95% CI 1.23, 1.48) for one standard deviation increase in age. Men were at greater risk of death than women (age-adjusted HR 1.44, 95% CI 1.19, 1.73). In a model adjusted for all study variables, Paired-Associate Learning (Cambridge Automated Neuropsychological Test Assessment Battery) and the psychotic factor of the Neuropsychiatric Inventory were significant predictors of survival. CONCLUSIONS: At diagnosis, in addition to the anticipated impact of age and gender, the presence of psychotic symptoms and poor performance on paired-associate learning are also indicators of poor prognosis. Copyright © 2011 John Wiley & Sons, Ltd.
PMID: 21956773 [PubMed - as supplied by publisher]
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Neuroscience
Neuropsychology Abstract of the Day: "Cognitive and Behavioural Predictors of Survival in Alzheimer Disease"
Cognitive and behavioural predictors of survival in Alzheimer disease: Results from a sample of treated patients in a tertiary-referral memory clinic
Int J Geriatr Psychiatry. 2011 Sep 29;
Russ TC, Batty GD, Starr JM
Abstract
OBJECTIVE: This study examined the influence of cognitive and non-cognitive factors at the time of diagnosis on the survival of patients with treated probable Alzheimer Disease (AD). METHODS: Consecutive patients seen at a regional, tertiary-referral clinic completed a battery of cognitive tests and assessments of activities of daily living and neuropsychiatric symptoms. These clinic data were linked with death certificate data for all individuals and survival from diagnosis was calculated. Cox regression models were constructed using the baseline covariates. RESULTS: The sample comprised 653 patients (459 women), mean age 77.1 years (SD 7.6, range 48-94 years), diagnosed with probable AD and treated with a cholinesterase inhibitor. In the survival analysis, age was a consistently significant predictor of survival with a gender-adjusted hazard ratio of 1.35 (95% CI 1.23, 1.48) for one standard deviation increase in age. Men were at greater risk of death than women (age-adjusted HR 1.44, 95% CI 1.19, 1.73). In a model adjusted for all study variables, Paired-Associate Learning (Cambridge Automated Neuropsychological Test Assessment Battery) and the psychotic factor of the Neuropsychiatric Inventory were significant predictors of survival. CONCLUSIONS: At diagnosis, in addition to the anticipated impact of age and gender, the presence of psychotic symptoms and poor performance on paired-associate learning are also indicators of poor prognosis. Copyright © 2011 John Wiley & Sons, Ltd.
PMID: 21956773 [PubMed - as supplied by publisher]
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There have been a number of excellent papers published over the past month in a number of different journals on the topic of Mild Cognitive Impairment (MCI). Looking forward to reading this new paper: An exploration of subgroups of mild cognitive impairment...
- Neuropsychology Abstract Of The Day: Alzheimer's Progression Rates
Doody RS, Pavlik V, Massman P, Rountree S, Darby E, & Chan W. Predicting progression of Alzheimer's disease. Alzheimers Res Ther. 2010 Feb 23; 2(1):2. [Epub ahead of print] Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine,...
- Neuropsychology Abstract Of The Day: Donepezil, Mci, And Ad
Lu PH, Edland SD, Teng E, Tingus K, Petersen RC, Cummings JL & Alzheimer's Disease Cooperative Study Group. (2009) Donepezil delays progression to AD in MCI subjects with depressive symptoms. Neurology, 72(24):, 2115-2121. Departments of Neurology,...
- Abstract Of The Day: Antihypertensive Medications And Alzheimer Disease
Khachaturian AS, Zandi PP, Lyketsos CG, Hayden KM, Skoog I, Norton MC, Tschanz JT, Mayer LS, Welsh-Bohmer KA, & Breitner JC. Antihypertensive Medication Use and Incident Alzheimer Disease: The Cache County Study. Archives of Neurology; 2006 Mar 13. [Epub...
- Abstract Of The Day: Dementia And Caregiver Quality Of Life
Thomas P, Lalloue F, Preux PM, Hazif-Thomas C, Pariel S, Inscale R, Belmin J, & Clement JP. Dementia patients caregivers quality of life: The PIXEL study. International Journal of Geriatric Psychiatry. 2005 Dec 2; [Epub ahead of print] University Department...