Neuroscience
Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis
Developmental Medicine and Child Neurology. 2012 Jan 28;
de Kieviet JF, Zoetebier L, van Elburg RM, Vermeulen RJ, Oosterlaan J
Abstract
Aim The aim of this article was to clarify the impact and consequences of very preterm birth (born <32wks of gestation) and/or very low birthweight ([VLBW], weighing <1500g) on brain volume development throughout childhood and adolescence. Method The computerized databases PubMed, Web of Knowledge, and EMBASE were searched for studies that reported volumetric outcomes during childhood or adolescence using magnetic resonance imaging and included a term-born comparison group. Fifteen studies were identified, encompassing 818 very preterm/VLBW children and 450 term-born peers. Average reductions in the total brain volume, white matter volume, grey matter volume, and in the size of the cerebellum, hippocampus, and corpus callosum were investigated using meta-analytic methods. Results Very preterm/VLBW children were found to have a significantly smaller total brain volume than the comparison group (d=-0.58; 95% confidence interval [CI] -0.43 to -0.73; p<0.001), smaller white matter volume (d=-0.53; CI -0.40 to -0.67; p<0.001), smaller grey matter volume (d=-0.62; CI -0.48 to -0.76; p<0.001), smaller cerebellum (d=-0.74; CI -0.56 to -0.92; p<0.001), smaller hippocampus (d=-0.47; CI -0.26 to -0.69; p<0.001), and smaller corpus callosum (d=-0.71; CI -0.34 to -1.07; p<0.001). Reductions have been associated with decreased general cognitive functioning, and no relations with age at assessment were found. Interpretation Very preterm/VLBW birth is associated with an overall reduction in brain volume, which becomes evident in equally sized reductions in white and grey matter volumes, as well as in volumes of diverse brain structures throughout childhood and adolescence.
PMID: 22283622 [PubMed - as supplied by publisher]
- Computerized Cognitive Testing
I noticed the abstract for this new paper earlier in the day. It should be a good read. Bauer RM, Iverson GL, Cernich AN, Binder LM, Ruff RM, Naugle RI (2012). Computerized neuropsychological assessment devices: Joint position paper of the American Academy...
- Great Ormond Street Hospital For Children
Neuropsychology at the Great Ormond Street Hospital for Children and the UCL Institute of Child Health View the website here From the homepage: "The Paediatric Neuropsychology Service consists of the Clinical Neuropsychology Department at Great Ormond...
- Abstract Of The Day: Neuropsychology Assessment In Outcome From Extremely Low Birth Weight (elbw)
Mikkola K, Ritari N, Tommiska V, Salokorpi T, Lehtonen L, Tammela O, Paakkonen L, Olsen P, Korkman M, & Fellman V. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996-1997. Pediatrics....
- Psyc Course Profile Of The Day: Psyc 355 Developmental Psychology!
PSYC Course Profile of the DayPSYC 355 Developmental Psychology In Developmental Psychology (PSYC355) you will learn: · What questions are of interest to developmental scientists and why · How these questions can be addressed using classic and...
- Research Volunteer Positions With Inova Fairfax Hospital!
The Department of Pediatrics and the Neonatal Intensive Care Unit at Inova Fairfax Hospital for Children in Northern Virginia are looking for a research volunteers to assess the neuropsychological development of preschool and school aged survivors of...
Neuroscience
Neuropsychology Abstract of the Day: Developmental Neuropsychology
Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis
Developmental Medicine and Child Neurology. 2012 Jan 28;
de Kieviet JF, Zoetebier L, van Elburg RM, Vermeulen RJ, Oosterlaan J
Abstract
Aim The aim of this article was to clarify the impact and consequences of very preterm birth (born <32wks of gestation) and/or very low birthweight ([VLBW], weighing <1500g) on brain volume development throughout childhood and adolescence. Method The computerized databases PubMed, Web of Knowledge, and EMBASE were searched for studies that reported volumetric outcomes during childhood or adolescence using magnetic resonance imaging and included a term-born comparison group. Fifteen studies were identified, encompassing 818 very preterm/VLBW children and 450 term-born peers. Average reductions in the total brain volume, white matter volume, grey matter volume, and in the size of the cerebellum, hippocampus, and corpus callosum were investigated using meta-analytic methods. Results Very preterm/VLBW children were found to have a significantly smaller total brain volume than the comparison group (d=-0.58; 95% confidence interval [CI] -0.43 to -0.73; p<0.001), smaller white matter volume (d=-0.53; CI -0.40 to -0.67; p<0.001), smaller grey matter volume (d=-0.62; CI -0.48 to -0.76; p<0.001), smaller cerebellum (d=-0.74; CI -0.56 to -0.92; p<0.001), smaller hippocampus (d=-0.47; CI -0.26 to -0.69; p<0.001), and smaller corpus callosum (d=-0.71; CI -0.34 to -1.07; p<0.001). Reductions have been associated with decreased general cognitive functioning, and no relations with age at assessment were found. Interpretation Very preterm/VLBW birth is associated with an overall reduction in brain volume, which becomes evident in equally sized reductions in white and grey matter volumes, as well as in volumes of diverse brain structures throughout childhood and adolescence.
PMID: 22283622 [PubMed - as supplied by publisher]
- Computerized Cognitive Testing
I noticed the abstract for this new paper earlier in the day. It should be a good read. Bauer RM, Iverson GL, Cernich AN, Binder LM, Ruff RM, Naugle RI (2012). Computerized neuropsychological assessment devices: Joint position paper of the American Academy...
- Great Ormond Street Hospital For Children
Neuropsychology at the Great Ormond Street Hospital for Children and the UCL Institute of Child Health View the website here From the homepage: "The Paediatric Neuropsychology Service consists of the Clinical Neuropsychology Department at Great Ormond...
- Abstract Of The Day: Neuropsychology Assessment In Outcome From Extremely Low Birth Weight (elbw)
Mikkola K, Ritari N, Tommiska V, Salokorpi T, Lehtonen L, Tammela O, Paakkonen L, Olsen P, Korkman M, & Fellman V. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996-1997. Pediatrics....
- Psyc Course Profile Of The Day: Psyc 355 Developmental Psychology!
PSYC Course Profile of the DayPSYC 355 Developmental Psychology In Developmental Psychology (PSYC355) you will learn: · What questions are of interest to developmental scientists and why · How these questions can be addressed using classic and...
- Research Volunteer Positions With Inova Fairfax Hospital!
The Department of Pediatrics and the Neonatal Intensive Care Unit at Inova Fairfax Hospital for Children in Northern Virginia are looking for a research volunteers to assess the neuropsychological development of preschool and school aged survivors of...