Neuroscience
Mikkola K, Ritari N, Tommiska V, Salokorpi T, Lehtonen L, Tammela O, Paakkonen L, Olsen P, Korkman M, & Fellman V. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996-1997. Pediatrics. 2005 Dec; 116(6): 1391-1400.
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.
OBJECTIVE: Increasing survival of extremely low birth weight (ELBW; birth weight < 1000 g) infants raises a concern regarding the risks of adverse long-term outcome such as cognitive dysfunction. Few studies have reported long-term follow-up of representative regional cohorts. The objective of this study was to assess the 5-year outcome of a prospectively followed national ELBW infant cohort. METHODS: Of all live-born ELBW infants (n = 351) who were delivered in the 2-year period 1996-1997 in Finland, 206 (59%) survived until the age of 5 years. Of these, 103 were born at < 27 gestational weeks (GW). A total of 172 children were assessed with neurocognitive tests (Wechsler Preschool and Primary Scale of Intelligence-Revised and a Developmental Neuropsychological Assessment [NEPSY]). Nine children with cognitive impairment and inability to cooperate in testing were not assessed. Motor development was assessed with a modified Touwen test. RESULTS: The rate of cognitive impairment in the ELBW survivors was 9%. The rate of cerebral palsy was 14% (19% of ELBW infants who were born at < 27 GW). The mean full-scale IQ of the assessed children was 96 +/- 19 and in children of GW < 27 was 94 +/- 19. Attention, language, sensorimotor, visuospatial, and verbal memory values of NEPSY assessment were significantly poorer compared with normal population means. Four percent needed a hearing aid, and 30% had ophthalmic findings. Of 21 children who had been treated with laser/cryo for retinopathy of prematurity, 17 (81%) had abnormal ophthalmic findings. Of the whole cohort, 41 (20%) exhibited major disabilities, 38 (19%) exhibited minor disabilities, and 124 (61%) showed development with no functional abnormalities but subtle departures from the norm. Only 53 (26%) of the total ELBW infant cohort were classified to have normal outcome excluding any abnormal ophthalmic, auditory, neurologic, or developmental findings. Being small for gestational age at birth was associated with suboptimal growth at least until age 5. CONCLUSIONS: Only one fourth of the ELBW infants were classified as normally developed at age 5. The high rate of cognitive dysfunction suggests an increased risk for learning difficulties that needs to be evaluated at a later age. Extended follow-up should be the rule in outcome studies of ELBW infant cohorts to elucidate the impact of immaturity on school achievement and social behavior later in life.
PMID: 16322163 [PubMed - in process]
-
Anthony H. Risser | neuroscience | neuropsychology | brain
- Why Season Of Birth Is Related To Childhood Intelligence
Countless studies have found that children’s intelligence appears to be related to the time of year they were born in. Some investigators have argued this is because seasonally varying environmental factors like temperature and infections can affect...
- Neuropsychology Abstract Of The Day: Developmental Neuropsychology
Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis Developmental Medicine and Child Neurology. 2012 Jan 28; de Kieviet JF, Zoetebier L, van Elburg RM, Vermeulen RJ, Oosterlaan J Abstract Aim ...
- Neuropsychology Abstract Of The Day: Perinatal Cortical Growth And Its Cognitive Correlates
Perinatal cortical growth and childhood neurocognitive abilities Neurology. 2011 Oct 12; Rathbone R, Counsell SJ, Kapellou O, Dyet L, Kennea N, Hajnal J, Allsop JM, Cowan F, Edwards AD Abstract OBJECTIVE:This observational cohort study addressed the hypothesis...
- Neuropsychology Abstract Of The Day: Cognitive Rehab In Ugandan Childhood Malaria Survivors
Bangirana P, Giordani B, John CC, Page C, Opoka RO, & Boivin MJ (2009). Immediate Neuropsychological and Behavioral Benefits of Computerized Cognitive Rehabilitation in Ugandan Pediatric Cerebral Malaria Survivors. Journal of Development and Behavioral...
- Nih Magnetic Resonance Imaging (mri) Study Of Normal Brain Development
From the NIH on the 18th of May: NIH Study Tracks Brain Development in Some 500 Children across U.S. First Report Looks at Intelligence, Behaviors from Ages 6-18 Children appear to approach adult levels of performance on many basic cognitive and motor...
Neuroscience
Abstract of the Day: Neuropsychology Assessment in Outcome from Extremely Low Birth Weight (ELBW)
Mikkola K, Ritari N, Tommiska V, Salokorpi T, Lehtonen L, Tammela O, Paakkonen L, Olsen P, Korkman M, & Fellman V. Neurodevelopmental outcome at 5 years of age of a national cohort of extremely low birth weight infants who were born in 1996-1997. Pediatrics. 2005 Dec; 116(6): 1391-1400.
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.
OBJECTIVE: Increasing survival of extremely low birth weight (ELBW; birth weight < 1000 g) infants raises a concern regarding the risks of adverse long-term outcome such as cognitive dysfunction. Few studies have reported long-term follow-up of representative regional cohorts. The objective of this study was to assess the 5-year outcome of a prospectively followed national ELBW infant cohort. METHODS: Of all live-born ELBW infants (n = 351) who were delivered in the 2-year period 1996-1997 in Finland, 206 (59%) survived until the age of 5 years. Of these, 103 were born at < 27 gestational weeks (GW). A total of 172 children were assessed with neurocognitive tests (Wechsler Preschool and Primary Scale of Intelligence-Revised and a Developmental Neuropsychological Assessment [NEPSY]). Nine children with cognitive impairment and inability to cooperate in testing were not assessed. Motor development was assessed with a modified Touwen test. RESULTS: The rate of cognitive impairment in the ELBW survivors was 9%. The rate of cerebral palsy was 14% (19% of ELBW infants who were born at < 27 GW). The mean full-scale IQ of the assessed children was 96 +/- 19 and in children of GW < 27 was 94 +/- 19. Attention, language, sensorimotor, visuospatial, and verbal memory values of NEPSY assessment were significantly poorer compared with normal population means. Four percent needed a hearing aid, and 30% had ophthalmic findings. Of 21 children who had been treated with laser/cryo for retinopathy of prematurity, 17 (81%) had abnormal ophthalmic findings. Of the whole cohort, 41 (20%) exhibited major disabilities, 38 (19%) exhibited minor disabilities, and 124 (61%) showed development with no functional abnormalities but subtle departures from the norm. Only 53 (26%) of the total ELBW infant cohort were classified to have normal outcome excluding any abnormal ophthalmic, auditory, neurologic, or developmental findings. Being small for gestational age at birth was associated with suboptimal growth at least until age 5. CONCLUSIONS: Only one fourth of the ELBW infants were classified as normally developed at age 5. The high rate of cognitive dysfunction suggests an increased risk for learning difficulties that needs to be evaluated at a later age. Extended follow-up should be the rule in outcome studies of ELBW infant cohorts to elucidate the impact of immaturity on school achievement and social behavior later in life.
PMID: 16322163 [PubMed - in process]
-
Anthony H. Risser | neuroscience | neuropsychology | brain
- Why Season Of Birth Is Related To Childhood Intelligence
Countless studies have found that children’s intelligence appears to be related to the time of year they were born in. Some investigators have argued this is because seasonally varying environmental factors like temperature and infections can affect...
- Neuropsychology Abstract Of The Day: Developmental Neuropsychology
Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis Developmental Medicine and Child Neurology. 2012 Jan 28; de Kieviet JF, Zoetebier L, van Elburg RM, Vermeulen RJ, Oosterlaan J Abstract Aim ...
- Neuropsychology Abstract Of The Day: Perinatal Cortical Growth And Its Cognitive Correlates
Perinatal cortical growth and childhood neurocognitive abilities Neurology. 2011 Oct 12; Rathbone R, Counsell SJ, Kapellou O, Dyet L, Kennea N, Hajnal J, Allsop JM, Cowan F, Edwards AD Abstract OBJECTIVE:This observational cohort study addressed the hypothesis...
- Neuropsychology Abstract Of The Day: Cognitive Rehab In Ugandan Childhood Malaria Survivors
Bangirana P, Giordani B, John CC, Page C, Opoka RO, & Boivin MJ (2009). Immediate Neuropsychological and Behavioral Benefits of Computerized Cognitive Rehabilitation in Ugandan Pediatric Cerebral Malaria Survivors. Journal of Development and Behavioral...
- Nih Magnetic Resonance Imaging (mri) Study Of Normal Brain Development
From the NIH on the 18th of May: NIH Study Tracks Brain Development in Some 500 Children across U.S. First Report Looks at Intelligence, Behaviors from Ages 6-18 Children appear to approach adult levels of performance on many basic cognitive and motor...