Neuroscience
Today's recommended reading addresses proposed efficacy measures for use in clinical trials related to traumatic brain injury (TBI):
Bagiella E, Novack TA, Ansel B, Diaz-Arrastia R, Dikmen S, Hart T, & Temkin N. Measuring Outcome in Traumatic Brain Injury Treatment Trials: Recommendations From the Traumatic Brain Injury Clinical Trials Network. Journal of Head Trauma Rehabilitation. 2010.
BACKGROUND: Traumatic brain injury (TBI) involves several aspects of a patient's condition, including physical, mental, emotional, cognitive, social, and functional changes. Therefore, a clinical trial with individuals with TBI should consider outcome measures that reflect their global status. METHODS: We present the work of the National Institute of Child Health and Development-sponsored Traumatic Brain Injury Clinical Trials Network Outcome Measures subcommittee and its choice of outcome measures for a phase III clinical trial of patients with complicated mild to severe TBI. RESULTS: On the basis of theoretical and practical considerations, the subcommittee recommended the adoption of a core of 9 measures that cover 2 different areas of recovery: functional and cognitive. These measures are the Extended Glasgow Outcome Scale; the Controlled Oral Word Association Test; the Trail Making Test, Parts A and B; the California Verbal Learning Test-II; the Wechsler Adult Intelligence Scale-III Digit Span subtest; the Wechsler Adult Intelligence Scale-III Processing Speed Index; and the Stroop Color-Word Matching Test, Parts 1 and 2. CONCLUSIONS: The statistical methods proposed to analyze these measures using a global test procedure, along with research and methodological and regulatory issues involved with the use of multiple outcomes in a clinical trial, are discussed.
PMID: 20216459 [PubMed - as supplied by publisher]
- Neuropsychology Abstract Of The Day: Traumatic Brain Injury (tbi)
Bayley MT, Tate R, Douglas JM, Turkstra LS, Ponsford J, Stergiou-Kita M, Kua A, & Bragge P. (2014). INCOG Guidelines for Cognitive Rehabilitation Following Traumatic Brain Injury: Methods and Overview. Journal of Head Trauma Rehabilitation, 29(4), 290-306....
- Neuropsychology Abstract Of The Day: Traumatic Brain Injury
Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? Journal of Clinical and Experimental Neuropsychology. 2011 Jul;33(6):704-14 Schiehser DM, Delis...
- Neuropsychology Abstract Of The Day: Assessment Of Social Cognition In Tbi
An active area of test development and research in contemporary clinical neuropsychology: Social Cognition Impairments in Relation to General Cognitive Deficits, Injury Severity and Prefrontal Lesions in Traumatic Brain Injury Patients. Journal of Neurotrauma....
- Unconsciousness
From tomorrow's Times, a feature article about the different states of unconsciousness and the different etiologies that may cause them to occur: Inside the Injured Brain, Many Kinds of Awareness The New York Times By BENEDICT CAREY Published: April...
- Abstract Of The Day: Deficit Awareness In Traumatic Brain Injury
Hart T, Sherer M, Whyte J, Polansky M, Novack TA. Awareness of behavioral, cognitive, and physical deficits in acute traumatic brain injury. Arch Phys Med Rehabil 2004; 85:1450-6. OBJECTIVE: To compare awareness of deficit in 3 domains of function...
Neuroscience
Neuropsychology Abstract of the Day: TBI Clinical Trials
Today's recommended reading addresses proposed efficacy measures for use in clinical trials related to traumatic brain injury (TBI):
Bagiella E, Novack TA, Ansel B, Diaz-Arrastia R, Dikmen S, Hart T, & Temkin N. Measuring Outcome in Traumatic Brain Injury Treatment Trials: Recommendations From the Traumatic Brain Injury Clinical Trials Network. Journal of Head Trauma Rehabilitation. 2010.
BACKGROUND: Traumatic brain injury (TBI) involves several aspects of a patient's condition, including physical, mental, emotional, cognitive, social, and functional changes. Therefore, a clinical trial with individuals with TBI should consider outcome measures that reflect their global status. METHODS: We present the work of the National Institute of Child Health and Development-sponsored Traumatic Brain Injury Clinical Trials Network Outcome Measures subcommittee and its choice of outcome measures for a phase III clinical trial of patients with complicated mild to severe TBI. RESULTS: On the basis of theoretical and practical considerations, the subcommittee recommended the adoption of a core of 9 measures that cover 2 different areas of recovery: functional and cognitive. These measures are the Extended Glasgow Outcome Scale; the Controlled Oral Word Association Test; the Trail Making Test, Parts A and B; the California Verbal Learning Test-II; the Wechsler Adult Intelligence Scale-III Digit Span subtest; the Wechsler Adult Intelligence Scale-III Processing Speed Index; and the Stroop Color-Word Matching Test, Parts 1 and 2. CONCLUSIONS: The statistical methods proposed to analyze these measures using a global test procedure, along with research and methodological and regulatory issues involved with the use of multiple outcomes in a clinical trial, are discussed.
PMID: 20216459 [PubMed - as supplied by publisher]
- Neuropsychology Abstract Of The Day: Traumatic Brain Injury (tbi)
Bayley MT, Tate R, Douglas JM, Turkstra LS, Ponsford J, Stergiou-Kita M, Kua A, & Bragge P. (2014). INCOG Guidelines for Cognitive Rehabilitation Following Traumatic Brain Injury: Methods and Overview. Journal of Head Trauma Rehabilitation, 29(4), 290-306....
- Neuropsychology Abstract Of The Day: Traumatic Brain Injury
Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? Journal of Clinical and Experimental Neuropsychology. 2011 Jul;33(6):704-14 Schiehser DM, Delis...
- Neuropsychology Abstract Of The Day: Assessment Of Social Cognition In Tbi
An active area of test development and research in contemporary clinical neuropsychology: Social Cognition Impairments in Relation to General Cognitive Deficits, Injury Severity and Prefrontal Lesions in Traumatic Brain Injury Patients. Journal of Neurotrauma....
- Unconsciousness
From tomorrow's Times, a feature article about the different states of unconsciousness and the different etiologies that may cause them to occur: Inside the Injured Brain, Many Kinds of Awareness The New York Times By BENEDICT CAREY Published: April...
- Abstract Of The Day: Deficit Awareness In Traumatic Brain Injury
Hart T, Sherer M, Whyte J, Polansky M, Novack TA. Awareness of behavioral, cognitive, and physical deficits in acute traumatic brain injury. Arch Phys Med Rehabil 2004; 85:1450-6. OBJECTIVE: To compare awareness of deficit in 3 domains of function...