Neuroscience
The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: A surface-based morphometric analysis
Neuropsychologia. 2011 Oct 15;
Ahn HJ, Seo SW, Chin J, Suh MK, Lee BH, Kim ST, Im K, Lee JM, Lee JH, Heilman KM, Na DL
Abstract
Patients with probable Alzheimer's disease (AD) and the amnesic form of mild cognitive impairment (aMCI) often demonstrate several types of neuropsychological deficits. These deficits are often related to cortical atrophy, induced by neuronal degradation. The purpose of this study is to investigate whether different anatomic patterns of cortical atrophy are associated with specific neuropsychological deficits. The participants were 170 patients with AD and 99 patients with aMCI. All participants underwent the Seoul Neuropsychological Screening Battery (SNSB), which includes tests that assess attention, language, visuospatial functions, verbal and visual memory, and frontal/executive functions. Cortical atrophy (thinning) was quantified by measuring the thickness of the cortical mantle across the entire brain using automated, three-dimensional magnetic resonance imaging. The relationship between cortical thickness and neuropsychological performance was analysed using stepwise multiple linear regression analyses. These analyses (corrected P<.001) showed that several specific brain regions with cortical thinning were associated with cognitive dysfunction including: digit span backward, verbal and picture recall, naming and fluency, drawing-copying, response inhibition and selective attention. Some of the other functions, however, were not associated with specific foci of cortical atrophy (digit span forward, the word reading portion of the Stroop test, word and picture recognition). Our study, involving a large sample of participants with aMCI and AD, provides support for the postulate that cortical thinning-atrophy in specific anatomic loci are pathological markers for specific forms of cognitive dysfunction.
PMID: 22019776 [PubMed - as supplied by publisher]
- Unusual Conference Advertising
ICAD 2008 FIGURE 1 (Mosconi et al., 2008). Representative cortical 18F-FDG PET patterns in NL, AD, DLB, and FTD. 3D-SSP maps and corresponding Z scores showing CMRglc reductions in clinical groups as compared with the NL database are displayed...
- Neuropsychology Abstract Of The Day: Hippocampal Function And Alzheimer's Disease
Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults Journal of Neuroscience. 2011 Nov 30; 31(48): 17680-17688 Putcha D, Brickhouse M, O'Keefe K, Sullivan C, Rentz...
- Neuropsychology Abstract Of The Day: Biomakers In Alzheimer's And Mild Cognitive Impairment
Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer JB, Dale AM; for the Alzheimer's Disease Neuroimaging Initiative. CSF Biomarkers in Prediction of Cerebral and Clinical Change in Mild Cognitive Impairment and Alzheimer's...
- Neuropsychology Abstract Of The Day: Parkinson's Disease
Pagonabarraga J, Kulisevsky J, Llebaria G, García-Sánchez C, Pascual-Sedano B, & Gironell A. Parkinson's disease-cognitive rating scale: A new cognitive scale specific for Parkinson's disease. Movement Disorders. 2008 Mar 31 [Epub ahead of print]....
- Abstract Of The Day: Neuropsychology Of Mild Cognitive Impairment (mci)
Lopez OL, Becker JT, Jagust W, Fitzpatrick A, Carlson M, T DU, Breitner J, Lyketsos C, Jones B, Kawas C, & Kuller LH. Neuropsychological characteristics of mild cognitive impairment subgroups. Journal of Neurology Neurosurgery and Psychiatry. 2005 Aug...
Neuroscience
Neuropsychology Abstract of the Day: Cortical Neuroanatomy of Neuropsychological Deficits
The cortical neuroanatomy of neuropsychological deficits in mild cognitive impairment and Alzheimer's disease: A surface-based morphometric analysis
Neuropsychologia. 2011 Oct 15;
Ahn HJ, Seo SW, Chin J, Suh MK, Lee BH, Kim ST, Im K, Lee JM, Lee JH, Heilman KM, Na DL
Abstract
Patients with probable Alzheimer's disease (AD) and the amnesic form of mild cognitive impairment (aMCI) often demonstrate several types of neuropsychological deficits. These deficits are often related to cortical atrophy, induced by neuronal degradation. The purpose of this study is to investigate whether different anatomic patterns of cortical atrophy are associated with specific neuropsychological deficits. The participants were 170 patients with AD and 99 patients with aMCI. All participants underwent the Seoul Neuropsychological Screening Battery (SNSB), which includes tests that assess attention, language, visuospatial functions, verbal and visual memory, and frontal/executive functions. Cortical atrophy (thinning) was quantified by measuring the thickness of the cortical mantle across the entire brain using automated, three-dimensional magnetic resonance imaging. The relationship between cortical thickness and neuropsychological performance was analysed using stepwise multiple linear regression analyses. These analyses (corrected P<.001) showed that several specific brain regions with cortical thinning were associated with cognitive dysfunction including: digit span backward, verbal and picture recall, naming and fluency, drawing-copying, response inhibition and selective attention. Some of the other functions, however, were not associated with specific foci of cortical atrophy (digit span forward, the word reading portion of the Stroop test, word and picture recognition). Our study, involving a large sample of participants with aMCI and AD, provides support for the postulate that cortical thinning-atrophy in specific anatomic loci are pathological markers for specific forms of cognitive dysfunction.
PMID: 22019776 [PubMed - as supplied by publisher]
- Unusual Conference Advertising
ICAD 2008 FIGURE 1 (Mosconi et al., 2008). Representative cortical 18F-FDG PET patterns in NL, AD, DLB, and FTD. 3D-SSP maps and corresponding Z scores showing CMRglc reductions in clinical groups as compared with the NL database are displayed...
- Neuropsychology Abstract Of The Day: Hippocampal Function And Alzheimer's Disease
Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults Journal of Neuroscience. 2011 Nov 30; 31(48): 17680-17688 Putcha D, Brickhouse M, O'Keefe K, Sullivan C, Rentz...
- Neuropsychology Abstract Of The Day: Biomakers In Alzheimer's And Mild Cognitive Impairment
Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer JB, Dale AM; for the Alzheimer's Disease Neuroimaging Initiative. CSF Biomarkers in Prediction of Cerebral and Clinical Change in Mild Cognitive Impairment and Alzheimer's...
- Neuropsychology Abstract Of The Day: Parkinson's Disease
Pagonabarraga J, Kulisevsky J, Llebaria G, García-Sánchez C, Pascual-Sedano B, & Gironell A. Parkinson's disease-cognitive rating scale: A new cognitive scale specific for Parkinson's disease. Movement Disorders. 2008 Mar 31 [Epub ahead of print]....
- Abstract Of The Day: Neuropsychology Of Mild Cognitive Impairment (mci)
Lopez OL, Becker JT, Jagust W, Fitzpatrick A, Carlson M, T DU, Breitner J, Lyketsos C, Jones B, Kawas C, & Kuller LH. Neuropsychological characteristics of mild cognitive impairment subgroups. Journal of Neurology Neurosurgery and Psychiatry. 2005 Aug...