Neuroscience
Neuropsychology Abstract of the Day: Assessing Non-motor Symptoms in Parkinson's Disease
Chaudhuri KR, Martinez-Martin P, Brown RG, Sethi K, Stocchi F, Odin P, Ondo W, Abe K, Macphee G, Macmahon D, Barone P, Rabey M, Forbes A, Breen K, Tluk S, Naidu Y, Olanow W, Williams AJ, Thomas S, Rye D, Tsuboi Y, Hand A, & Schapira AH.
The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study. Movement Disorders. 2007 Aug 2; [Epub ahead of print].
National Parkinson Foundation Centre of Excellence, Kings College Hospital, London, United Kingdom.
Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 +/- 11 years, duration of disease 6.4 +/- 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 +/- 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean alpha, 0.61). Factor analysis supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and health-related quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire. (c) 2007 Movement Disorder Society.
PMID: 17674410 [PubMed - as supplied by publisher]
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Neuropsychology Abstract Of The Day: Disability Scale For Dm1
Development of a disability scale for myotonic dystrophy type 1. Acta Neurol Scand. 2011 Sep 8; Authors: Contardi S, Pizza F, Falzone F, D'Alessandro R, Avoni P, Di Stasi V, Montagna P, Liguori R Abstract Objectives - Myotonic dystrophy type 1...
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Neuropsychology Abstract Of The Day: Parkinson's Disease
Pagonabarraga J, Kulisevsky J, Llebaria G, García-Sánchez C, Pascual-Sedano B, & Gironell A. Parkinson's disease-cognitive rating scale: A new cognitive scale specific for Parkinson's disease. Movement Disorders. 2008 Mar 31 [Epub ahead of print]....
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Abstract Of The Day: Dementia And Caregiver Quality Of Life
Thomas P, Lalloue F, Preux PM, Hazif-Thomas C, Pariel S, Inscale R, Belmin J, & Clement JP. Dementia patients caregivers quality of life: The PIXEL study. International Journal of Geriatric Psychiatry. 2005 Dec 2; [Epub ahead of print] University Department...
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Abstract Of The Day: Fatigue And Parkinson Disease
Alves G, Wentzel-Larsen T, Larsen JP. Is fatigue an independent and persistent symptom in patients with Parkinson disease? Neurology. 2004 Nov 23; 63(10): 1908-11.
Department of Neurology, Rogaland Central Hospital, Postboks 8100, N-4068 Stavanger,...
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Awareness Month: Parkinson’s Disease
April is National Parkinson's Awareness Month. Parkinson’s disease, a degenerative disorder of the central nervous system, has no known cause in most cases. Medically, Parkinson’s has been traced to the death of dopamine-generating cells in the...
Neuroscience