Neuroscience
Alves G, Wentzel-Larsen T, Larsen JP. Is fatigue an independent and persistent symptom in patients with Parkinson disease? Neurology. 2004 Nov 23; 63(10): 1908-11.
Department of Neurology, Rogaland Central Hospital, Postboks 8100, N-4068 Stavanger, Norway.
OBJECTIVE: To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS: In 1993, 233 patients with PD were included in a community-based study of fatigue and followed prospectively over 8 years. Fatigue was measured by a combination of a seven-point scale and parts of the Nottingham Health Profile (NHP) at baseline and after 4 and 8 years. In addition, the Fatigue Severity Scale (FSS) was used to evaluate fatigue in 2001. Population-averaged logistic regression models for correlated data were performed to study the relationship between fatigue and various demographic and clinical variables. RESULTS: In patients who were followed throughout the 8-year study period, fatigue increased from 35.7% in 1993 to 42.9% in 1997 and 55.7% in 2001. Fatigue was related to disease progression, depression, and excessive daytime sleepiness (EDS). However, the prevalence of fatigue in patients without depression and EDS remained high and increased from 32.1% to 38.9% during the study period. For about 44% of the patients with fatigue the presence of this symptom varied during the study period, as it was persistent in 56% of the patients with fatigue. CONCLUSIONS: The authors confirmed the high prevalence of mental fatigue in patients with Parkinson disease (PD). Fatigue is related to other non-motor features such as depression and excessive daytime sleepiness, but cannot be explained by this comorbidity alone. In more than half of the patients mental fatigue is persistent and seems to be an independent symptom that develops parallel to the progressive neurodegenerative disorder of PD.
PMID: 15557510 [PubMed - in process]
- Neuropsychology Abstract Of The Day: Fatigue
Möller MC, Nygren de Boussard C, Oldenburg C, & Bartfai A. (2014). An investigation of attention, executive, and psychomotor aspects of cognitive fatigability. Journal of Clinical and Experimental Neuropsychology. 2014 Jun 26:1-14. [Epub ahead of print]...
- Neuropsychology Abstract Of The Day: Multiple Sclerosis, Fatigue, And Cognition
Morrow S, Weinstock-Guttman B, Munschauer F, Hojnacki D, & Benedict R. (2009). Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis. Multiple Sclerosis, 15(8),:998-1005. School...
- Neuropsychology Abstract Of The Day: Patient-reported Outcome Measurement For Fatigue
Christodoulou C, Junghaenel DU, Dewalt DA, Rothrock N, & Stone AA. Cognitive interviewing in the evaluation of fatigue items: Results from the patient-reported outcomes measurement information system (PROMIS). Quality of Life Research. 2008 Oct 12. [Epub...
- Neuropsychology Abstract Of The Day: Adhd Drivers
Reimer B, D'Ambrosio LA, Coughlin JF, Fried R, & Biederman J. Task-induced fatigue and collisions in adult drivers with attention deficit hyperactivity disorder. Traffic Inj Prev. 2007 Sep; 8(3): 290-299. AgeLab, Massachusetts Institute of Technology,...
- Modafinil For Fatigue In Multiple Sclerosis
B. Stankoff, MD, PhD, E. Waubant, MD, PhD, C. Confavreux, MD, G. Edan, MD, M. Debouverie, MD, L. Rumbach, MD, T. Moreau, MD, PhD, J. Pelletier, MD, PhD, C. Lubetzki, MD, PhD, M. Clanet, MD, PhD and French Modafinil Study Group. Modafinil for fatigue in...
Neuroscience
Abstract of the Day: Fatigue and Parkinson Disease
Alves G, Wentzel-Larsen T, Larsen JP. Is fatigue an independent and persistent symptom in patients with Parkinson disease? Neurology. 2004 Nov 23; 63(10): 1908-11.
Department of Neurology, Rogaland Central Hospital, Postboks 8100, N-4068 Stavanger, Norway.
OBJECTIVE: To evaluate if mental fatigue is a symptom that appears independently from other clinical features in patients with Parkinson disease (PD), and to study if fatigue is persistent over time in these patients. METHODS: In 1993, 233 patients with PD were included in a community-based study of fatigue and followed prospectively over 8 years. Fatigue was measured by a combination of a seven-point scale and parts of the Nottingham Health Profile (NHP) at baseline and after 4 and 8 years. In addition, the Fatigue Severity Scale (FSS) was used to evaluate fatigue in 2001. Population-averaged logistic regression models for correlated data were performed to study the relationship between fatigue and various demographic and clinical variables. RESULTS: In patients who were followed throughout the 8-year study period, fatigue increased from 35.7% in 1993 to 42.9% in 1997 and 55.7% in 2001. Fatigue was related to disease progression, depression, and excessive daytime sleepiness (EDS). However, the prevalence of fatigue in patients without depression and EDS remained high and increased from 32.1% to 38.9% during the study period. For about 44% of the patients with fatigue the presence of this symptom varied during the study period, as it was persistent in 56% of the patients with fatigue. CONCLUSIONS: The authors confirmed the high prevalence of mental fatigue in patients with Parkinson disease (PD). Fatigue is related to other non-motor features such as depression and excessive daytime sleepiness, but cannot be explained by this comorbidity alone. In more than half of the patients mental fatigue is persistent and seems to be an independent symptom that develops parallel to the progressive neurodegenerative disorder of PD.
PMID: 15557510 [PubMed - in process]
- Neuropsychology Abstract Of The Day: Fatigue
Möller MC, Nygren de Boussard C, Oldenburg C, & Bartfai A. (2014). An investigation of attention, executive, and psychomotor aspects of cognitive fatigability. Journal of Clinical and Experimental Neuropsychology. 2014 Jun 26:1-14. [Epub ahead of print]...
- Neuropsychology Abstract Of The Day: Multiple Sclerosis, Fatigue, And Cognition
Morrow S, Weinstock-Guttman B, Munschauer F, Hojnacki D, & Benedict R. (2009). Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis. Multiple Sclerosis, 15(8),:998-1005. School...
- Neuropsychology Abstract Of The Day: Patient-reported Outcome Measurement For Fatigue
Christodoulou C, Junghaenel DU, Dewalt DA, Rothrock N, & Stone AA. Cognitive interviewing in the evaluation of fatigue items: Results from the patient-reported outcomes measurement information system (PROMIS). Quality of Life Research. 2008 Oct 12. [Epub...
- Neuropsychology Abstract Of The Day: Adhd Drivers
Reimer B, D'Ambrosio LA, Coughlin JF, Fried R, & Biederman J. Task-induced fatigue and collisions in adult drivers with attention deficit hyperactivity disorder. Traffic Inj Prev. 2007 Sep; 8(3): 290-299. AgeLab, Massachusetts Institute of Technology,...
- Modafinil For Fatigue In Multiple Sclerosis
B. Stankoff, MD, PhD, E. Waubant, MD, PhD, C. Confavreux, MD, G. Edan, MD, M. Debouverie, MD, L. Rumbach, MD, T. Moreau, MD, PhD, J. Pelletier, MD, PhD, C. Lubetzki, MD, PhD, M. Clanet, MD, PhD and French Modafinil Study Group. Modafinil for fatigue in...