Neuroscience
O'Sullivan M, Morris RG, & Markus HS. Brief cognitive assessment for patients with cerebral small vessel disease. Journal of Neurology, Neurosurgery, and Psychiatry. 2005 Aug; 76(8): 1140-1145.
Division of Clinical Neuroscience, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
BACKGROUND: Cerebral small vessel disease is a common cause of cognitive impairment and vascular dementia. The cognitive deficit differs from that in Alzheimer's disease, with greater executive/attentional dysfunction and relatively intact episodic memory. OBJECTIVE: To develop brief assessment tools that are better adapted to the neuropsychological profile of cerebral small vessel disease. METHODS: 32 subjects with ischaemic leukoaraiosis (history of lacunar stroke and leukoaraiosis on MRI), aged 50 to 84 years, and 17 age and education matched controls had a brief executive assessment, which took 20 minutes to administer, and a wide range of additional tests. The ability of the brief executive assessment to discriminate between groups-both individually and in combination-was evaluated and compared with that of the whole battery. RESULTS: The brief executive assessment provided good sensitivity and specificity for identifying subjects with ischaemic leukoaraiosis (sensitivity 88%, specificity 88%, using the optimal combination of scores). The best individual tests were trail making and digit symbol, which were both far more sensitive than the mini-mental state examination (MMSE). The ability to discriminate between groups was maintained in subjects with MMSE >27 and across the whole age range. The brief executive assessment performed well compared with the whole battery, with additional tests accounting for only a further 12% of between-group variance. CONCLUSIONS: The brief executive assessment was sensitive to deficits found in ischaemic leukoaraiosis and discriminated them from the cognitive effects of healthy aging. The assessment has potential for bedside use and as a cognitive end point for clinical trials.
PMID: 16024894 [PubMed - as supplied by publisher]
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Anthony H. Risser | neuroscience | neuropsychology | brain
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Neuroscience
Abstract of the Day: Neuropsychological Assessment
O'Sullivan M, Morris RG, & Markus HS. Brief cognitive assessment for patients with cerebral small vessel disease. Journal of Neurology, Neurosurgery, and Psychiatry. 2005 Aug; 76(8): 1140-1145.
Division of Clinical Neuroscience, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
BACKGROUND: Cerebral small vessel disease is a common cause of cognitive impairment and vascular dementia. The cognitive deficit differs from that in Alzheimer's disease, with greater executive/attentional dysfunction and relatively intact episodic memory. OBJECTIVE: To develop brief assessment tools that are better adapted to the neuropsychological profile of cerebral small vessel disease. METHODS: 32 subjects with ischaemic leukoaraiosis (history of lacunar stroke and leukoaraiosis on MRI), aged 50 to 84 years, and 17 age and education matched controls had a brief executive assessment, which took 20 minutes to administer, and a wide range of additional tests. The ability of the brief executive assessment to discriminate between groups-both individually and in combination-was evaluated and compared with that of the whole battery. RESULTS: The brief executive assessment provided good sensitivity and specificity for identifying subjects with ischaemic leukoaraiosis (sensitivity 88%, specificity 88%, using the optimal combination of scores). The best individual tests were trail making and digit symbol, which were both far more sensitive than the mini-mental state examination (MMSE). The ability to discriminate between groups was maintained in subjects with MMSE >27 and across the whole age range. The brief executive assessment performed well compared with the whole battery, with additional tests accounting for only a further 12% of between-group variance. CONCLUSIONS: The brief executive assessment was sensitive to deficits found in ischaemic leukoaraiosis and discriminated them from the cognitive effects of healthy aging. The assessment has potential for bedside use and as a cognitive end point for clinical trials.
PMID: 16024894 [PubMed - as supplied by publisher]
-
Anthony H. Risser | neuroscience | neuropsychology | brain
- Neuropsychology Abstract Of The Day: Fatigue
Möller MC, Nygren de Boussard C, Oldenburg C, & Bartfai A. (2014). An investigation of attention, executive, and psychomotor aspects of cognitive fatigability. Journal of Clinical and Experimental Neuropsychology. 2014 Jun 26:1-14. [Epub ahead of print]...
- Computerized Cognitive Testing: A New Cogstate Paper
Reliability of repeated cognitive assessment of dementia using a brief computerized battery American Journal of Alzheimers Disease and Other Dementias. 2011 Jun; 26(4): 326-333. Hammers D, Spurgeon E, Ryan K, Persad C, Heidebrink J, Barbas N, Albin R,...
- Neuropsychology Abstract Of The Day: Alzheimer's Disease
Relationships Between Behavioral Syndromes and Cognitive Domains in Alzheimer Disease: The Impact of Mood and Psychosis American Journal of Geriatric Psychiatry. 2011 Nov 1; Koppel J, Goldberg TE, Gordon ML, Huey E, Davies P, Keehlisen L, Huet S, Christen...
- Neuropsychology Abstract Of The Day: Aging And Mci Screening
Today's recommended read deals with an important neuropsychological assessment issue in the domain of aging and the potential to identify the presence of cognitive problems that might (emphasis on "might" - such findings in a screen are not definitive)...
- Neuropsychology Abstract Of The Day: Chronic Congestive Heart Failure And Neuropsychological Function
Vogels RL, Oosterman JM, van Harten B, Scheltens P, van der Flier WM, Schroeder-Tanka JM, & Weinstein HC. Profile of Cognitive Impairment in Chronic Heart Failure. Journal of the American Geriatrics Society. 2007 Aug 28; [Epub ahead of print]. Department...