Neuroscience
Nakagawasai O, Yamadera F, Sato S, Taniguchi R, Hiraga H, Arai Y, Murakami H, Mawatari K, Niijima F, Tan-No K, & Tadano T. Alterations in cognitive function in prepubertal mice with protein malnutrition: relationship to changes in choline acetyltransferase. Behavior and Brain Research. 2006 Feb 15; 167(1): 111-117.
Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
We have found that protein malnutrition (PM) causes a significant impairment of memory-related behavior on the 15th and 20th day after the start of PM (5% casein) feeding in prepubertal mice but not in postpubertal mice, as measured by a passive-avoidance task. This impairment was almost completely reversed by merely switching to a standard protein (20% casein) diet on the 10th day after the start of PM. However, the reversal was not observed when the switching to a standard protein regimen was done on the 15th day of the PM diet. Interestingly, the impairment of memory-related behavior on the 20th day was improved by the chronic administration of physostigmine (0.1 mg/kg/day x last 10 days, i.p.), a cholinesterase inhibitor. To correlate brain cholinergic neuron function with the memory-related behavior impairment induced by PM, microphotometry was used to determine the histological distribution of the imunofluorescence intensity for choline acetyltransferase (ChAT), a functional marker of presynapse in cholinergic neurons. The change in the intensity of fluorescence indicated that ChAT protein was decreased in the hippocampus (CA1, CA3 and dentate gyrus) on the 20th day after PM feeding in comparison with controls. These results suggest the possibility that the memory-related behavior deficits observed in prepubertal mice with PM are caused by a dysfunction of the cholinergic neurons in the hippocampus.
PMID: 16242790 [PubMed - indexed for MEDLINE]
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Anthony H. Risser | neuroscience | neuropsychology | brain
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Bartko SJ, Vendrell I, Saksida LM, & Bussey TJ A computer-automated touchscreen paired-associates learning (PAL) task for mice: Impairments following administration of scopolamine or dicyclomine and improvements following donepezil. Psychopharmacology...
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Neuroscience
Abstract of the Day: Malnutrition
Nakagawasai O, Yamadera F, Sato S, Taniguchi R, Hiraga H, Arai Y, Murakami H, Mawatari K, Niijima F, Tan-No K, & Tadano T. Alterations in cognitive function in prepubertal mice with protein malnutrition: relationship to changes in choline acetyltransferase. Behavior and Brain Research. 2006 Feb 15; 167(1): 111-117.
Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
We have found that protein malnutrition (PM) causes a significant impairment of memory-related behavior on the 15th and 20th day after the start of PM (5% casein) feeding in prepubertal mice but not in postpubertal mice, as measured by a passive-avoidance task. This impairment was almost completely reversed by merely switching to a standard protein (20% casein) diet on the 10th day after the start of PM. However, the reversal was not observed when the switching to a standard protein regimen was done on the 15th day of the PM diet. Interestingly, the impairment of memory-related behavior on the 20th day was improved by the chronic administration of physostigmine (0.1 mg/kg/day x last 10 days, i.p.), a cholinesterase inhibitor. To correlate brain cholinergic neuron function with the memory-related behavior impairment induced by PM, microphotometry was used to determine the histological distribution of the imunofluorescence intensity for choline acetyltransferase (ChAT), a functional marker of presynapse in cholinergic neurons. The change in the intensity of fluorescence indicated that ChAT protein was decreased in the hippocampus (CA1, CA3 and dentate gyrus) on the 20th day after PM feeding in comparison with controls. These results suggest the possibility that the memory-related behavior deficits observed in prepubertal mice with PM are caused by a dysfunction of the cholinergic neurons in the hippocampus.
PMID: 16242790 [PubMed - indexed for MEDLINE]
-
Anthony H. Risser | neuroscience | neuropsychology | brain
- Neuropsychology Abstract Of The Day: Samp8
Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice. Neurol Sci. 2012 Aug 8; Authors: Li G, Cheng H, Zhang X, Shang X, Xie H, Zhang X, Yu J, Han JAbstractThe objective of this study is to examine whether neuron loss occurs in SAMP8...
- Neuropsychology Abstract Of The Day: Memory Formation
Visualizing long-term memory formation in two neurons of the Drosophila brain Science. 2012 Feb 10;335(6069):678-85 Chen CC, Wu JK, Lin HW, Pai TP, Fu TF, Wu CL, Tully T, Chiang AS Abstract Long-term memory (LTM) depends on the synthesis of new proteins....
- Neuropsychology Abstract Of The Day: Amyloid
Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation Neuron. 2011 Sep 8; 71(5): 833-844. Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König S, Roeber S, Jessen F, Klockgether...
- Neuropsychology Abstract Of The Day: Mouse Paired Associates Learning (pal) Task
Bartko SJ, Vendrell I, Saksida LM, & Bussey TJ A computer-automated touchscreen paired-associates learning (PAL) task for mice: Impairments following administration of scopolamine or dicyclomine and improvements following donepezil. Psychopharmacology...
- Abstract Of The Day: Assessing Neurocognitive Toxicity In Animal Models
Bertaina-Anglade V, Enjuanes E, Morillon D, & Drieu la Rochelle C. (2006). The object recognition task in rats and mice: A simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity. J Pharmacol Toxicol Methods,...