Neuroscience
Morrow S, Weinstock-Guttman B, Munschauer F, Hojnacki D, & Benedict R. (2009). Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis. Multiple Sclerosis, 15(8),:998-1005.
School of Medicine, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA.
Background Studies in multiple sclerosis (MS) report conflicting conclusions regarding fatigue and cognition, which may partly be due to the use of small sample sizes and frequent reliance on a cross-sectional approach. Objective The ability to distinguish between these two disabling symptoms is necessary in order to properly assess and treat MS patients. Methods In a retrospective analysis, we assessed the correlation between fatigue and neuropsychological (NP) testing using a cross-sectional (n = 465) and longitudinal approach (n = 69). Cognition was measured using a comprehensive battery called the Minimal Assessment of Cognitive Function in MS (MACFIMS), and fatigue was measured with the Fatigue Severity Scale (FSS). FSS scores were categorized as normal (< /=4.0), borderline fatigue (4 < FSS < 5.0), and fatigued ( >/=5.0). Repeat assessments (n = 69) were categorized as improved or worsened by a change in FSS of either 0.5 or 1.0. Results MS patients had significantly higher FSS scores than normal controls (P < 0.001). No correlation was found between FSS and NP scores in either cross-sectional or longitudinal analyses. Fatigue was moderately correlated with depression, assessed using the Beck Depression Inventory Fast Screen (BDIFS) (r = 0.44, P < 0.001). Longitudinally, there was a medium correlation between change in FSS and BDIFS (r = 0.34, P = 0.001), but no significant differences on NP scores using either definition of change. Conclusion We conclude that self-reported fatigue, while correlated with self-reported depression, is not significantly related to cognitive capacity in MS.
PMID: 19667024 [PubMed - in process]
- Neuropsychology Abstract Of The Day: Fatigue
Möller MC, Nygren de Boussard C, Oldenburg C, & Bartfai A. (2014). An investigation of attention, executive, and psychomotor aspects of cognitive fatigability. Journal of Clinical and Experimental Neuropsychology. 2014 Jun 26:1-14. [Epub ahead of print]...
- Neuropsychology Abstract Of The Day: Ms And Cognitive Rehabilitation
A randomized controlled trial of a cognitive rehabilitation intervention for persons with multiple sclerosis Clin Rehabil. 2012 Feb 2; Stuifbergen AK, Becker H, Perez F, Morison J, Kullberg V, Todd A Abstract Objective: To explore the feasibility and...
- Neuropsychology Abstract Of The Day: Adhd Drivers
Reimer B, D'Ambrosio LA, Coughlin JF, Fried R, & Biederman J. Task-induced fatigue and collisions in adult drivers with attention deficit hyperactivity disorder. Traffic Inj Prev. 2007 Sep; 8(3): 290-299. AgeLab, Massachusetts Institute of Technology,...
- Neuropsychology Abstract Of The Day: Modafinil And Fatigue In Depression
Lam JY, Freeman MK, & Gates ME. Modafinil augmentation for residual symptoms of fatigue in patients with a partial response to antidepressants. Annals of Pharmacotherapy. 2007 Jun;41(6):1005-12. Epub 2007 May 22. University of Alabama Health System-Birmingham,...
- Modafinil For Fatigue In Multiple Sclerosis
B. Stankoff, MD, PhD, E. Waubant, MD, PhD, C. Confavreux, MD, G. Edan, MD, M. Debouverie, MD, L. Rumbach, MD, T. Moreau, MD, PhD, J. Pelletier, MD, PhD, C. Lubetzki, MD, PhD, M. Clanet, MD, PhD and French Modafinil Study Group. Modafinil for fatigue in...
Neuroscience
Neuropsychology Abstract of the Day: Multiple Sclerosis, Fatigue, and Cognition
Morrow S, Weinstock-Guttman B, Munschauer F, Hojnacki D, & Benedict R. (2009). Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis. Multiple Sclerosis, 15(8),:998-1005.
School of Medicine, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York, USA.
Background Studies in multiple sclerosis (MS) report conflicting conclusions regarding fatigue and cognition, which may partly be due to the use of small sample sizes and frequent reliance on a cross-sectional approach. Objective The ability to distinguish between these two disabling symptoms is necessary in order to properly assess and treat MS patients. Methods In a retrospective analysis, we assessed the correlation between fatigue and neuropsychological (NP) testing using a cross-sectional (n = 465) and longitudinal approach (n = 69). Cognition was measured using a comprehensive battery called the Minimal Assessment of Cognitive Function in MS (MACFIMS), and fatigue was measured with the Fatigue Severity Scale (FSS). FSS scores were categorized as normal (< /=4.0), borderline fatigue (4 < FSS < 5.0), and fatigued ( >/=5.0). Repeat assessments (n = 69) were categorized as improved or worsened by a change in FSS of either 0.5 or 1.0. Results MS patients had significantly higher FSS scores than normal controls (P < 0.001). No correlation was found between FSS and NP scores in either cross-sectional or longitudinal analyses. Fatigue was moderately correlated with depression, assessed using the Beck Depression Inventory Fast Screen (BDIFS) (r = 0.44, P < 0.001). Longitudinally, there was a medium correlation between change in FSS and BDIFS (r = 0.34, P = 0.001), but no significant differences on NP scores using either definition of change. Conclusion We conclude that self-reported fatigue, while correlated with self-reported depression, is not significantly related to cognitive capacity in MS.
PMID: 19667024 [PubMed - in process]
- Neuropsychology Abstract Of The Day: Fatigue
Möller MC, Nygren de Boussard C, Oldenburg C, & Bartfai A. (2014). An investigation of attention, executive, and psychomotor aspects of cognitive fatigability. Journal of Clinical and Experimental Neuropsychology. 2014 Jun 26:1-14. [Epub ahead of print]...
- Neuropsychology Abstract Of The Day: Ms And Cognitive Rehabilitation
A randomized controlled trial of a cognitive rehabilitation intervention for persons with multiple sclerosis Clin Rehabil. 2012 Feb 2; Stuifbergen AK, Becker H, Perez F, Morison J, Kullberg V, Todd A Abstract Objective: To explore the feasibility and...
- Neuropsychology Abstract Of The Day: Adhd Drivers
Reimer B, D'Ambrosio LA, Coughlin JF, Fried R, & Biederman J. Task-induced fatigue and collisions in adult drivers with attention deficit hyperactivity disorder. Traffic Inj Prev. 2007 Sep; 8(3): 290-299. AgeLab, Massachusetts Institute of Technology,...
- Neuropsychology Abstract Of The Day: Modafinil And Fatigue In Depression
Lam JY, Freeman MK, & Gates ME. Modafinil augmentation for residual symptoms of fatigue in patients with a partial response to antidepressants. Annals of Pharmacotherapy. 2007 Jun;41(6):1005-12. Epub 2007 May 22. University of Alabama Health System-Birmingham,...
- Modafinil For Fatigue In Multiple Sclerosis
B. Stankoff, MD, PhD, E. Waubant, MD, PhD, C. Confavreux, MD, G. Edan, MD, M. Debouverie, MD, L. Rumbach, MD, T. Moreau, MD, PhD, J. Pelletier, MD, PhD, C. Lubetzki, MD, PhD, M. Clanet, MD, PhD and French Modafinil Study Group. Modafinil for fatigue in...