Neuroscience
Atchison TB, Bradshaw M, Massman PJ. Investigation of profile difference between Alzheimer's disease patients declining at different rates: Examination of baseline neuropsychological data. Archives of Clinical Neuropsychology. 2004 Dec; 19(8): 1007-1015.
Department of Psychology, University of Houston, USA.
The rate of cognitive decline in AD has been noted to vary significantly among patients. The ability to predict the probable rate of decline early in the disease process would be of great practical importance. Attempts to analyze early cognitive deficits to find patterns associated with rapid decline have met with limited success. This paper utilized a large sample of patients with a diagnosis of probable AD evaluated longitudinally in ongoing research at the ADRC at Baylor College of Medicine and a statistical procedure of profile analysis to assess the initial data for a pattern associated with rapid decline. The findings indicated that despite initial equality of MMSE scores, patients showing rapid MMSE decline at one year displayed significantly more impaired performance on neuropsychological measures at diagnosis. Discussion includes discussion on the use of the MMSE for tracking general cognitive function and the difficulties of ascertaining stable profiles for prediction.
PMID: 15533693 [PubMed - as supplied by publisher]
- Neuropsychology Abstract Of The Day: Cognitive Intervention In Amnestic Mci And Mild Alzheimer's Disease
Effects of a 6-Month Cognitive Intervention on Brain Metabolism in Patients with Amnestic MCI and Mild Alzheimer's Disease. Journal of Alzheimers Disease. 2011 Jan 1;26(0):337-48 Authors: Förster S, Buschert VC, Teipel SJ, Friese U, Buchholz HG,...
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Doody RS, Pavlik V, Massman P, Rountree S, Darby E, & Chan W. Predicting progression of Alzheimer's disease. Alzheimers Res Ther. 2010 Feb 23; 2(1):2. [Epub ahead of print] Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine,...
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de Jong LW, van der Hiele K, Veer IM, Houwing JJ, Westendorp RG, Bollen EL, de Bruin PW, Middelkoop HA, van Buchem MA, & van der Grond J. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: An MRI study. Brain. 2008 Nov 20. Department...
- Abstract Of The Day: Alzheimer Disease
Pavlik VN, Doody RS, Massman PJ, & Chan W. (2006). Influence of premorbid IQ and education on progression of Alzheimer's Disease. Dementia, Geriatrics, & Cognitive Disorders,22(4), 367-377. [Epub ahead of print] Department of Family and Community...
- Abstract Of The Day: Mild Cognitive Impairment (mci) & Dementia
Hodges JR, Erzinclioglu S, & Patterson K. Evolution of Cognitive Deficits and Conversion to Dementia in Patients with Mild Cognitive Impairment: A Very-Long-Term Follow-Up Study. Dementia and Geriatric Cognitive Disorders. 2006 Apr 4; 21(5-6): 380-391...
Neuroscience
Abstract of the Day: Alzheimer Disease
Atchison TB, Bradshaw M, Massman PJ. Investigation of profile difference between Alzheimer's disease patients declining at different rates: Examination of baseline neuropsychological data. Archives of Clinical Neuropsychology. 2004 Dec; 19(8): 1007-1015.
Department of Psychology, University of Houston, USA.
The rate of cognitive decline in AD has been noted to vary significantly among patients. The ability to predict the probable rate of decline early in the disease process would be of great practical importance. Attempts to analyze early cognitive deficits to find patterns associated with rapid decline have met with limited success. This paper utilized a large sample of patients with a diagnosis of probable AD evaluated longitudinally in ongoing research at the ADRC at Baylor College of Medicine and a statistical procedure of profile analysis to assess the initial data for a pattern associated with rapid decline. The findings indicated that despite initial equality of MMSE scores, patients showing rapid MMSE decline at one year displayed significantly more impaired performance on neuropsychological measures at diagnosis. Discussion includes discussion on the use of the MMSE for tracking general cognitive function and the difficulties of ascertaining stable profiles for prediction.
PMID: 15533693 [PubMed - as supplied by publisher]
- Neuropsychology Abstract Of The Day: Cognitive Intervention In Amnestic Mci And Mild Alzheimer's Disease
Effects of a 6-Month Cognitive Intervention on Brain Metabolism in Patients with Amnestic MCI and Mild Alzheimer's Disease. Journal of Alzheimers Disease. 2011 Jan 1;26(0):337-48 Authors: Förster S, Buschert VC, Teipel SJ, Friese U, Buchholz HG,...
- Neuropsychology Abstract Of The Day: Alzheimer's Progression Rates
Doody RS, Pavlik V, Massman P, Rountree S, Darby E, & Chan W. Predicting progression of Alzheimer's disease. Alzheimers Res Ther. 2010 Feb 23; 2(1):2. [Epub ahead of print] Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine,...
- Neuropsychology Abstract Of The Day: Neurodegeneration In Alzheimer Disease
de Jong LW, van der Hiele K, Veer IM, Houwing JJ, Westendorp RG, Bollen EL, de Bruin PW, Middelkoop HA, van Buchem MA, & van der Grond J. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: An MRI study. Brain. 2008 Nov 20. Department...
- Abstract Of The Day: Alzheimer Disease
Pavlik VN, Doody RS, Massman PJ, & Chan W. (2006). Influence of premorbid IQ and education on progression of Alzheimer's Disease. Dementia, Geriatrics, & Cognitive Disorders,22(4), 367-377. [Epub ahead of print] Department of Family and Community...
- Abstract Of The Day: Mild Cognitive Impairment (mci) & Dementia
Hodges JR, Erzinclioglu S, & Patterson K. Evolution of Cognitive Deficits and Conversion to Dementia in Patients with Mild Cognitive Impairment: A Very-Long-Term Follow-Up Study. Dementia and Geriatric Cognitive Disorders. 2006 Apr 4; 21(5-6): 380-391...