Neuroscience
Nathan PC, Patel SK, Dilley K, Goldsby R, Harvey J, Jacobsen C, Kadan-Lottick N, McKinley K, Millham AK, Moore I, Okcu MF, Woodman CL, Brouwers P, Armstrong FD; Children's Oncology Group Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childhood Cancer. Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: A report from the Children's Oncology Group. Archives of Pediatric and Adolescent Medicine. 2007 Aug; 161(8): 798-806.
Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada.
With modern therapies and supportive care, survival of childhood cancer has increased considerably. Patients who have survived cancers involving the central nervous system or who have received therapy toxic to the developing brain are at risk of long-term neurocognitive sequelae. Negative outcomes are observed most frequently in survivors of acute lymphoblastic leukemia and brain tumors. The Children's Oncology Group Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childhood Cancer has generated risk-based, exposure-related guidelines designed to direct the follow-up care of survivors of pediatric malignancies based on a comprehensive literature review and expert opinion. This article expands on these guidelines by reviewing the risk factors for the development of neurocognitive sequelae and describing the expected pattern of these disabilities. We herein present recommendations for the screening and management of neurocognitive late effects and outline important areas of school and legal advocacy for survivors with disabilities. Finally, we list resources that can guide patients, their parents, and their medical caregivers as they face the long-term neurocognitive consequences of cancer therapy.
PMID: 17679663 [PubMed - indexed for MEDLINE]
- Abstract Of The Day: Ritalin In Childhood Cancer Survivors
Mulhern RK, Khan RB, Kaplan S, Helton S, Christensen R, Bonner M, Brown R, Xiong X, Wu S, Gururangan S, Reddick WE. Short-term efficacy of methylphenidate: A randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. Journal...
- Medulloblastoma
Targeted therapy knocks out pediatric brain cancer in mice Scientists have identified what may be the first nontoxic treatment for a subset of medulloblastoma, the most common type of malignant pediatric brain tumor. The finding is encouraging in that...
- Focus On Brain Cancer: Discovery To Recovery
The Focus On Brain Cancer: Discovery to Recovery conference is sponsored by the Abramson Cancer Center. The Focus On Brain Cancer conference is for adults who are newly diagnosed, in treatment of survivors of brain cancer. At this conference, adults with...
- Shaping The Future Of Brain Tumor Research
Join some of the top researchers from around the country as they discuss the future of brain tumor research at the Shaping the Future of Brain Tumor Research Event Detailsseminar on Friday, June 21, 2013. This event is sponsored by the Abramson Cancer...
- Steven Brem, Md Receives American Brain Tumor Association Award
Steven Brem, MD, Professor of Neurosurgery, Chief of the Division of Neurosurgical Oncology and Co-Director of the Penn Brain Tumor Center, has received the first Joel A. Gingras, Jr. award given by the American Brain Tumor Association (ABTA). Dr. Brem...
Neuroscience
Neuropsychology Abstract of the Day: Cognitive Function in Pediatric Neuro-oncology
Nathan PC, Patel SK, Dilley K, Goldsby R, Harvey J, Jacobsen C, Kadan-Lottick N, McKinley K, Millham AK, Moore I, Okcu MF, Woodman CL, Brouwers P, Armstrong FD; Children's Oncology Group Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childhood Cancer. Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: A report from the Children's Oncology Group. Archives of Pediatric and Adolescent Medicine. 2007 Aug; 161(8): 798-806.
Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada.
With modern therapies and supportive care, survival of childhood cancer has increased considerably. Patients who have survived cancers involving the central nervous system or who have received therapy toxic to the developing brain are at risk of long-term neurocognitive sequelae. Negative outcomes are observed most frequently in survivors of acute lymphoblastic leukemia and brain tumors. The Children's Oncology Group Long-term Follow-up Guidelines Task Force on Neurocognitive/Behavioral Complications After Childhood Cancer has generated risk-based, exposure-related guidelines designed to direct the follow-up care of survivors of pediatric malignancies based on a comprehensive literature review and expert opinion. This article expands on these guidelines by reviewing the risk factors for the development of neurocognitive sequelae and describing the expected pattern of these disabilities. We herein present recommendations for the screening and management of neurocognitive late effects and outline important areas of school and legal advocacy for survivors with disabilities. Finally, we list resources that can guide patients, their parents, and their medical caregivers as they face the long-term neurocognitive consequences of cancer therapy.
PMID: 17679663 [PubMed - indexed for MEDLINE]
- Abstract Of The Day: Ritalin In Childhood Cancer Survivors
Mulhern RK, Khan RB, Kaplan S, Helton S, Christensen R, Bonner M, Brown R, Xiong X, Wu S, Gururangan S, Reddick WE. Short-term efficacy of methylphenidate: A randomized, double-blind, placebo-controlled trial among survivors of childhood cancer. Journal...
- Medulloblastoma
Targeted therapy knocks out pediatric brain cancer in mice Scientists have identified what may be the first nontoxic treatment for a subset of medulloblastoma, the most common type of malignant pediatric brain tumor. The finding is encouraging in that...
- Focus On Brain Cancer: Discovery To Recovery
The Focus On Brain Cancer: Discovery to Recovery conference is sponsored by the Abramson Cancer Center. The Focus On Brain Cancer conference is for adults who are newly diagnosed, in treatment of survivors of brain cancer. At this conference, adults with...
- Shaping The Future Of Brain Tumor Research
Join some of the top researchers from around the country as they discuss the future of brain tumor research at the Shaping the Future of Brain Tumor Research Event Detailsseminar on Friday, June 21, 2013. This event is sponsored by the Abramson Cancer...
- Steven Brem, Md Receives American Brain Tumor Association Award
Steven Brem, MD, Professor of Neurosurgery, Chief of the Division of Neurosurgical Oncology and Co-Director of the Penn Brain Tumor Center, has received the first Joel A. Gingras, Jr. award given by the American Brain Tumor Association (ABTA). Dr. Brem...