Neuroscience
Atchison TB, Massman PJ, & Doody RS. Baseline cognitive function predicts rate of decline in basic-care abilities of individuals with dementia of the Alzheimer's type. Archives of Clinical Neuropsychology. 2006 Dec 13; [Epub ahead of print].
Department of Psychology, Sociology, and Social Work, West Texas A&M University, Box 60296, Canyon, TX 79016-0001, United States.
Decline in basic self-care abilities is an important risk factor for institutionalization in individuals with dementia. The ability to predict such decline would be of clinical importance in working with families of dementia patients. Research has suggested that cognitive decline may precede loss of functional capacity. This paper utilized a large sample of probable Alzheimer's disease patients (N=150) who were evaluated longitudinally to assess the pattern of neuropsychological functioning predictive of rapid decline in self-care. The findings indicated that despite initial equality of Lawton Physical Self-Maintenance (PSM) scores, patients showing rapid decline of PSM function displayed significantly more impaired performance on neuropsychological measures at diagnosis. They also exhibited a statistically significant difference in the pattern of scores from patients who remained stable. The pattern of the rapid declining group included more severe impairment in visual spatial skills, processing speed, and concept formation. Difficulties in using individual patients' cognitive profiles to make predictions about future rate of PSM decline are discussed.
PMID: 17174522 [PubMed - as supplied by publisher]
- Alzheimer's Disease: Gammagard Fails
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From the NIH: NIH State-of-the-Science Conference: Preventing Alzheimer's Disease and Cognitive Decline - Day 1 View event: You will be able to view the event at http://videocast.nih.gov when the event is live. Air date: Monday, April 26, 2010, 8:30:00...
- Abstract Of The Day: Alzheimer Disease
Pavlik VN, Doody RS, Massman PJ, & Chan W. (2006). Influence of premorbid IQ and education on progression of Alzheimer's Disease. Dementia, Geriatrics, & Cognitive Disorders,22(4), 367-377. [Epub ahead of print] Department of Family and Community...
- Abstract Of The Day: Mild Cognitive Impairment (mci) & Dementia
Hodges JR, Erzinclioglu S, & Patterson K. Evolution of Cognitive Deficits and Conversion to Dementia in Patients with Mild Cognitive Impairment: A Very-Long-Term Follow-Up Study. Dementia and Geriatric Cognitive Disorders. 2006 Apr 4; 21(5-6): 380-391...
- Abstract Of The Day: Olfactory Functioning
Wilson RS, Arnold SE, Tang Y, & Bennett DA. Odor identification and decline in different cognitive domains in old age. Neuroepidemiology. 2006; 26(2): 61-67. Rush Alzheimer's Disease Center, Rush Institute for Healthy Aging, and Department of Neurological...
Neuroscience
Neuropsychology Abstract of the Day: Alzheimer Disease
Atchison TB, Massman PJ, & Doody RS. Baseline cognitive function predicts rate of decline in basic-care abilities of individuals with dementia of the Alzheimer's type. Archives of Clinical Neuropsychology. 2006 Dec 13; [Epub ahead of print].
Department of Psychology, Sociology, and Social Work, West Texas A&M University, Box 60296, Canyon, TX 79016-0001, United States.
Decline in basic self-care abilities is an important risk factor for institutionalization in individuals with dementia. The ability to predict such decline would be of clinical importance in working with families of dementia patients. Research has suggested that cognitive decline may precede loss of functional capacity. This paper utilized a large sample of probable Alzheimer's disease patients (N=150) who were evaluated longitudinally to assess the pattern of neuropsychological functioning predictive of rapid decline in self-care. The findings indicated that despite initial equality of Lawton Physical Self-Maintenance (PSM) scores, patients showing rapid decline of PSM function displayed significantly more impaired performance on neuropsychological measures at diagnosis. They also exhibited a statistically significant difference in the pattern of scores from patients who remained stable. The pattern of the rapid declining group included more severe impairment in visual spatial skills, processing speed, and concept formation. Difficulties in using individual patients' cognitive profiles to make predictions about future rate of PSM decline are discussed.
PMID: 17174522 [PubMed - as supplied by publisher]
- Alzheimer's Disease: Gammagard Fails
From the company press release: Baxter Announces Topline Results of Phase III Study of Immunoglobulin for Alzheimer's Disease DEERFIELD, Ill., May 7, 2013 - Baxter International Inc. (NYSE:BAX) today announced that its Phase III clinical study of...
- Alzheimer's Disease: Watch Nih Conference Live Online
From the NIH: NIH State-of-the-Science Conference: Preventing Alzheimer's Disease and Cognitive Decline - Day 1 View event: You will be able to view the event at http://videocast.nih.gov when the event is live. Air date: Monday, April 26, 2010, 8:30:00...
- Abstract Of The Day: Alzheimer Disease
Pavlik VN, Doody RS, Massman PJ, & Chan W. (2006). Influence of premorbid IQ and education on progression of Alzheimer's Disease. Dementia, Geriatrics, & Cognitive Disorders,22(4), 367-377. [Epub ahead of print] Department of Family and Community...
- Abstract Of The Day: Mild Cognitive Impairment (mci) & Dementia
Hodges JR, Erzinclioglu S, & Patterson K. Evolution of Cognitive Deficits and Conversion to Dementia in Patients with Mild Cognitive Impairment: A Very-Long-Term Follow-Up Study. Dementia and Geriatric Cognitive Disorders. 2006 Apr 4; 21(5-6): 380-391...
- Abstract Of The Day: Olfactory Functioning
Wilson RS, Arnold SE, Tang Y, & Bennett DA. Odor identification and decline in different cognitive domains in old age. Neuroepidemiology. 2006; 26(2): 61-67. Rush Alzheimer's Disease Center, Rush Institute for Healthy Aging, and Department of Neurological...