Gamma Knife® Perfexion
Neuroscience

Gamma Knife® Perfexion



Image courtesy of Elekta

Gamma Knife® PerfexionTM is the latest form of radiation therapy that damages cancer cells and tumors, and prevents them from multiplying. It does not involve surgery, but rather precise beams of radiation delivered to the tumor. 

The first Gamma Knife unit was developed in 1968 and primarily used for the treatment of intractable pain and movement disorders. Gamma Knife technology has evolved over the past 40 years—today, the Penn Gamma Knife Center provides treatment for a variety of neurological disorders, including:

• Brain metastasis
• Acoustic neuroma / vestibular schwannoma
• Meningioma 
• Pituitary adenoma 
• Glioma / astrocytoma 
• Chordoma 
• Craniopharyngioma 
• Hemangioblastoma 
• Arteriovenous malformations (AVM) 
• Arteriovenous fistulas (AVF) 
• Cavernous malformations 
• Trigeminal neuralgia / tic douloureux 
• Epilepsy 
• Tremor
• Other disorders

“Gamma Knife was developed specifically for the brain and is used exclusively for the treatment of neurological conditions - whereas other radiation options including CyberKnife® treat conditions throughout the entire body,” states John Y.K. Lee, MD, medical director of the Penn Gamma Knife Center and assistant professor of neurosurgery. 

The Gamma Knife®  PerfexionTM unit from Elekta Instrument, a Swedish medical device manufacturer, is completely redesigned and represents the fifth generation of gamma knife stereotactic radiosurgery technology. Perfexion uses 192 sources of radiation to precisely target tumors, lesions and other intracranial structures. Compared with earlier Gamma Knife versions, Perfexion offers an expanded reach for treatment of metastasis anywhere in the brain and can also treat multiple locations in a single session.

Each year, Penn Neurosurgery treats as many as 300 patients in the Penn Gamma Knife Center—the most of any hospital in the Philadelphia region.  The Center collaborates with the Penn Brain Tumor Center and Penn’s Abramson Cancer Center  offering patients a comprehensive range of services and care options. 

Learn more about Gamma Knife services at Penn, request a consultation or refer a patient.

Penn Medicine offers the Philadelphia region's most comprehensive treatment options for benign and malignant tumors originating in the brain, as well as metastatic cancer including:

• Gamma Knife® Perfexion™
• Proton therapy 
• CyberKnife®
• Intensity-modulated radiation therapy (IMRT)





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