Neuroscience
A news release from the NIH:
Targeting the Blood-Brain Barrier May Delay Progression of Alzheimer's Disease
12 April 2010
Read the full release
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Neuroscience
Alzheimer's Disease: Targeting the Blood-Brain Barrier
A news release from the NIH:
Targeting the Blood-Brain Barrier May Delay Progression of Alzheimer's Disease
12 April 2010
Researchers may be one step closer to slowing the onset and progression of Alzheimer's disease. An animal study supported by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, shows that by targeting the blood-brain barrier, researchers are able to slow the accumulation of a protein associated with the progression of the illness. The blood-brain barrier separates the brain from circulating blood, and it protects the brain by removing toxic metabolites and proteins formed in the brain and preventing entry of toxic chemicals from the blood.
"This study may provide the experimental basis for new strategies that can be used to treat Alzheimer’s patients," said David S. Miller, Ph.D., chief of the Laboratory of Toxicology and Pharmacology at NIEHS and an author on the paper that appears in the May issue of Molecular Pharmacology.
[snip]
"What we've shown in our mouse models is that we can reduce the accumulation of beta-amyloid protein in the brain by targeting a certain receptor in the brain known as the pregnane X receptor, or PXR," said Miller.
Read the full release
- Alzheimer's Disease
In Preventing Alzheimer’s, Mutation May Aid Drug Quest The New York Times By GINA KOLATA 11 July 2012 [snip] Two decades ago, researchers began discovering rare gene mutations that cause Alzheimer’s disease in all who inherit them. Now, they have...
- Neuropsychology Abstract Of The Day: Alzheimer's Disease Pharmacologic Strategies
New pharmacological strategies for treatment of Alzheimer's disease: focus on disease-modifying drugs British Journal of Clinical Pharmacology. 2011 Oct 28; Salomone S, Caraci F, Leggio GM, Fedotova J, Drago F Abstract Current approved drug treatments...
- Upcoming: Alzheimer's: Fda Advisory Committee Meeting (20-21 January 2011)
From the FDA (.pdfs of briefing material is available at the link below): January 20-21, 2011: Peripheral and Central Nervous System Drugs Advisory Committee Meeting Announcement Read the full announcementAgenda "On January 20, 2011, the committee will...
- Alzheimer's: Impaired Beta-amyloid Clearance
From the NIH: Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer’s disease 09 December 2010 In Alzheimer's disease, a protein fragment called beta-amyloid accumulates at abnormally high levels in the brain. Now researchers...
- Fibril Structure And Alzheimer Disease
From a Salk Institute for Biological Studies press release:Released: Fri 11-Nov-2005, 08:55 ET Embargo expired: Mon 14-Nov-2005, 17:00 ET 3-D Structure of Alzheimer's Disease Filament Shows How It Zips Up Peptides Newswise — Researchers...