Neuroscience
From The Boston Globe:
- Alzheimer's Disease: New Risk Genes Discovered
From Cardiff University News Centre: New Alzheimer’s risk genes discovered in record study 27 October 2013 "In the largest ever study of its kind, an international collaboration of scientists, jointly led by Cardiff, has uncovered 11 new susceptibility...
- Alzheimer's: Impaired Beta-amyloid Clearance
From the NIH: Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer’s disease 09 December 2010 In Alzheimer's disease, a protein fragment called beta-amyloid accumulates at abnormally high levels in the brain. Now researchers...
- Neuropsychology Abstract Of The Day: Alzheimer Drug Development
Today's recommended article to read; abstract from PubMed: Bergmans BA & De Strooper B. gamma-secretases: From cell biology to therapeutic strategies. Lancet Neurology. 2010 Feb; 9(2 ): 215-226. Department of Molecular and Developmental Genetics,...
- World Alzheimer's Day
Today is World Alzheimer's Day. Read something today to increase your knowledge about the disease and dementia. Here's a general-readership resource: Alzheimer's Disease: Unraveling the Mystery ... and a report from the Alzheimer's Association:...
- Upcoming Event:alzheimer's Drug Discovery (jersey City, Nj, 14-15 September)
The 10th international conference on Alzheimer's disease drug discovery takes place next week on the 14th and 15th in Jersey City, NJ. From the conference website: "The 10th International Conference on Alzheimer's Disease Drug Discovery is presented...
Neuroscience
Alzheimer Disease
From The Boston Globe:
[ ... Read the full article ... ]
Mind mystery
Alzheimer's disease appears to have multiple causes, and scientists are slowly unraveling them
By Alice Dembner, Globe Staff
March 29, 2005
A century after Alois Alzheimer identified the debilitating dementia that carries his name, scientists are still trying to determine what causes the disease in old age. Their quest takes on increasing urgency, with predictions that unless a cure is found, the number of Americans with the disease will rise from about 4.5 million now to 13 million in 2050.
Many scientists believe that Alzheimer’s results from a complex interplay of environmental factors, lifestyle choices, and genes and proteins gone haywire. But the changes in the brain that characterize the disease develop over decades and also occur in some healthy seniors, making it difficult to sort out the culprits from the bystanders.
Yet, tantalizing tidbits have surfaced in the last few weeks, including discovery of a new genetic mutation that appears to increase the risk of getting Alzheimer’s and new evidence that insulin deficiencies may contribute to deterioration of the brain.
‘‘The pieces are coming together. We’ve got the outline of the puzzle in place, and we’re beginning to see the form,’’ said Stephen Snyder, who oversees research on the causes of Alzheimer’s for the National Institute on Aging. ‘‘It’s probably five or six genes and a dozen proteins that get out of kilter,’’ said Snyder, and certainly not just the sticky clumps of proteins called beta-amyloid plaques that have received the most attention.
- Alzheimer's Disease: New Risk Genes Discovered
From Cardiff University News Centre: New Alzheimer’s risk genes discovered in record study 27 October 2013 "In the largest ever study of its kind, an international collaboration of scientists, jointly led by Cardiff, has uncovered 11 new susceptibility...
- Alzheimer's: Impaired Beta-amyloid Clearance
From the NIH: Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer’s disease 09 December 2010 In Alzheimer's disease, a protein fragment called beta-amyloid accumulates at abnormally high levels in the brain. Now researchers...
- Neuropsychology Abstract Of The Day: Alzheimer Drug Development
Today's recommended article to read; abstract from PubMed: Bergmans BA & De Strooper B. gamma-secretases: From cell biology to therapeutic strategies. Lancet Neurology. 2010 Feb; 9(2 ): 215-226. Department of Molecular and Developmental Genetics,...
- World Alzheimer's Day
Today is World Alzheimer's Day. Read something today to increase your knowledge about the disease and dementia. Here's a general-readership resource: Alzheimer's Disease: Unraveling the Mystery ... and a report from the Alzheimer's Association:...
- Upcoming Event:alzheimer's Drug Discovery (jersey City, Nj, 14-15 September)
The 10th international conference on Alzheimer's disease drug discovery takes place next week on the 14th and 15th in Jersey City, NJ. From the conference website: "The 10th International Conference on Alzheimer's Disease Drug Discovery is presented...