Neuroscience
From medicalnewstoday.com:
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Anthony H. Risser | neuroscience | neuropsychology | brain
- The Joy Of 5-ht4 Receptors
Move over, melanocortin receptors, 5-HT4 receptors are ready to take your place. Agonists of the 5-HT4 receptor, a subtype of the serotonin receptor family, seem to do the following, according to recently published reports: (1) mediate the appetite-suppressing...
- Neuropsychology Abstract Of The Day: Samp8
Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice. Neurol Sci. 2012 Aug 8; Authors: Li G, Cheng H, Zhang X, Shang X, Xie H, Zhang X, Yu J, Han JAbstractThe objective of this study is to examine whether neuron loss occurs in SAMP8...
- Clinical Trials: Solanezumab In Alzheimer's Disease
From Bloomberg: Eli Lilly Shares Rise on Alzheimer’s Drug Hopes By Drew Armstrong and Robert Langreth Dec 6, 2011 [snip] "Solanezumab is an antibody designed to clear protein fragments called beta amyloid that clutter the brains of patients with Alzheimer’s...
- Early Diagnosis Of Alzheimer Disease And Fddnp
From today's New York Times: New Chemical Is Said to Provide Early Sign of Alzheimer’s Disease By REUTERS The New York Times Published: December 21, 2006 chem Originally uploaded by rissera. A chemical designed by doctors in Los Angeles...
- Synapse-associated Protein 97 (sap97): Pdz1
From a Brown University press release (the press release includes a graphic showing a portion of the protein):Researchers Reveal Secret of Key Protein in Brain and Heart Function 29 July 2005 Brown University researchers have solved the structure of a...
Neuroscience
AF267B and Alzheimer Disease
From medicalnewstoday.com:
Experimental Drug Reverses Key Cognitive Deficits, Pathology In Alzheimer's
Main Category: Alzheimer's News
Article Date: 04 Mar 2006 - 13:00pm (UK)
A new drug that enhances the activity of a key brain cell receptor involved in Alzheimer's disease (AD) reverses learning and memory deficits in mice engineered to have pathological hallmarks of the disease. What's more, the drug, called AF267B, reduces both of the pathologies--the brain-clogging buildup of protein "amyloid plaque" outside brain cells and the protein "neurofibrillary tangles" inside the cells.
In an article in the March 2, 2006, issue of Neuron, Dr. Frank LaFerla of the University of California, Irvine and his colleagues reported the first in vivo studies of the drug's effects. AF267B was developed by coauthor Abraham Fisher to activate particular receptors for the neurotransmitter acetylcholine. These specific receptors, called M1 receptors, are abundant in areas of the brain--the cortex and hippocampus--known to develop severe deposits of plaques and tangles in AD patients. Dysfunction in acetylcholine receptors has been shown to be characteristic of early stages of AD.
[ ... Read the full press release ... ]
-
Anthony H. Risser | neuroscience | neuropsychology | brain
- The Joy Of 5-ht4 Receptors
Move over, melanocortin receptors, 5-HT4 receptors are ready to take your place. Agonists of the 5-HT4 receptor, a subtype of the serotonin receptor family, seem to do the following, according to recently published reports: (1) mediate the appetite-suppressing...
- Neuropsychology Abstract Of The Day: Samp8
Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice. Neurol Sci. 2012 Aug 8; Authors: Li G, Cheng H, Zhang X, Shang X, Xie H, Zhang X, Yu J, Han JAbstractThe objective of this study is to examine whether neuron loss occurs in SAMP8...
- Clinical Trials: Solanezumab In Alzheimer's Disease
From Bloomberg: Eli Lilly Shares Rise on Alzheimer’s Drug Hopes By Drew Armstrong and Robert Langreth Dec 6, 2011 [snip] "Solanezumab is an antibody designed to clear protein fragments called beta amyloid that clutter the brains of patients with Alzheimer’s...
- Early Diagnosis Of Alzheimer Disease And Fddnp
From today's New York Times: New Chemical Is Said to Provide Early Sign of Alzheimer’s Disease By REUTERS The New York Times Published: December 21, 2006 chem Originally uploaded by rissera. A chemical designed by doctors in Los Angeles...
- Synapse-associated Protein 97 (sap97): Pdz1
From a Brown University press release (the press release includes a graphic showing a portion of the protein):Researchers Reveal Secret of Key Protein in Brain and Heart Function 29 July 2005 Brown University researchers have solved the structure of a...