Neuroscience
VK Srikanth et al. Progressive dementia after first-ever stroke: A community-based follow-up study. Neurology 2004; 63:785-792.
Address correspondence and reprint requests to Prof. Geoffrey A. Donnan, Director, National Stroke Research Institute, Neurosciences Building, Repatriation Hospital, Austin Health, 300 Waterdale Rd., Heidelberg Heights, Victoria 3081, Australia.
Objectives: To examine the risk and determinants of a progressive dementia syndrome and cognitive impairment not dementia (CIND) in community-based nonaphasic first-ever stroke cases 1 year after stroke, relative to a matched community-based stroke-free group.
Methods: Matched cohort design, with cognitive tests given on two occasions 9 months apart to 99 mild-to-moderate first-ever stroke patients and 99 age- and sex-matched people without stroke. At follow-up, progressive dementia or CIND were diagnosed, with judges blinded to stroke/nonstroke status.
Results: Progressive dementia was diagnosed in 12.5% of stroke patients and 15.4% of those without strokes (RR 1.1, 95% CI 0.5 to 2.2, p = 0.85). CIND was diagnosed in 37.5% of stroke patients and 17.6% of participants without strokes (RR 2.1, 95% CI 1.2 to 3.4, p = 0.003). In multivariable regression, age (p = 0.04) and baseline cognition (p < 0.001) were independently associated with dementia whereas stroke (p = 0.002), age (p = 0.05), baseline cognition (p = 0.001), and baseline mood (p = 0.03) were independently associated with CIND at follow-up.
Conclusions: In this community-based nonaphasic sample, mild-to moderate first-ever stroke was not associated with the presence of progressive dementia 1 year later, but was clearly associated with a greater risk of cognitive impairment not dementia (CIND). Baseline mood impairment remained independently associated with CIND at 1 year after taking into account stroke, age, and baseline cognitive ability.
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Neuroscience
Abstract of the Day: Stroke and Cognition
VK Srikanth et al. Progressive dementia after first-ever stroke: A community-based follow-up study. Neurology 2004; 63:785-792.
Address correspondence and reprint requests to Prof. Geoffrey A. Donnan, Director, National Stroke Research Institute, Neurosciences Building, Repatriation Hospital, Austin Health, 300 Waterdale Rd., Heidelberg Heights, Victoria 3081, Australia.
Objectives: To examine the risk and determinants of a progressive dementia syndrome and cognitive impairment not dementia (CIND) in community-based nonaphasic first-ever stroke cases 1 year after stroke, relative to a matched community-based stroke-free group.
Methods: Matched cohort design, with cognitive tests given on two occasions 9 months apart to 99 mild-to-moderate first-ever stroke patients and 99 age- and sex-matched people without stroke. At follow-up, progressive dementia or CIND were diagnosed, with judges blinded to stroke/nonstroke status.
Results: Progressive dementia was diagnosed in 12.5% of stroke patients and 15.4% of those without strokes (RR 1.1, 95% CI 0.5 to 2.2, p = 0.85). CIND was diagnosed in 37.5% of stroke patients and 17.6% of participants without strokes (RR 2.1, 95% CI 1.2 to 3.4, p = 0.003). In multivariable regression, age (p = 0.04) and baseline cognition (p < 0.001) were independently associated with dementia whereas stroke (p = 0.002), age (p = 0.05), baseline cognition (p = 0.001), and baseline mood (p = 0.03) were independently associated with CIND at follow-up.
Conclusions: In this community-based nonaphasic sample, mild-to moderate first-ever stroke was not associated with the presence of progressive dementia 1 year later, but was clearly associated with a greater risk of cognitive impairment not dementia (CIND). Baseline mood impairment remained independently associated with CIND at 1 year after taking into account stroke, age, and baseline cognitive ability.
- Neuropsychology Abstract Of The Day: Moyamoya
Intellectual ability and executive function in pediatric moyamoya vasculopathy Developmental Medicine and Child Neurology. 2011 Nov 24; Williams TS, Westmacott R, Dlamini N, Granite L, Dirks P, Askalan R, Macgregor D, Moharir M, Deveber G Abstract Aim ...
- Neuropsychology Abstract Of The Day: Aphasia Screening For Stroke Patients
Validation of the language component of the Addenbrooke's Cognitive Examination - Revised (ACE-R) as a screening tool for aphasia in stroke patients. Australas J Ageing. 2011 Sep;30(3):156-8 Authors: Gaber TA, Parsons F, Gautam V Abstract Aim: ...
- Neuropsychology Abstract Of The Day: Donepezil And Aphasia
Chen Y, Li YS, Wang ZY, Xu Q, Shi GW, & Lin Y. [The efficacy of donepezil for post-stroke aphasia: a pilot case control study.] Zhonghua Nei Ke Za Zhi. 2010 Feb, 49(2), 115-118. OBJECTIVE: To evaluate the efficacy of donepezil for post-stroke aphasia....
- Transient Ischemic Attack (tia)
From the BBC:Test 'identifies new stroke risk' Doctors have developed a simple checklist to show if patients who have had a mini-stroke are at immediate risk of a more serious attack. The Oxford University team, writing in the Lancet, said it...
- Hup Becomes First Hospital In Philadelphia To Earn Joint Commission And Aha/asa Certified Comprehensive Stroke Center Status
The Hospital of the University of Pennsylvania (HUP) has been recognized by The Joint Commission and the American Heart Association/American Stroke Association (AHA/ASA) as meeting The Joint Commission’s standards for Disease-Specific Care Comprehensive...