Neuroscience
Clark DG, Charuvastra A, Miller BL, Shapira JS, Mendez MF. Fluent versus nonfluent primary progressive aphasia: A comparison of clinical and functional neuroimaging features. Brain and Language 2005 Jul; 94(1): 54-60.
David Geffen School of Medicine, Department of Neurology, University of California-Los Angeles, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., 3-South Neurobehavior Unit (116AF), Los Angeles, CA 90073, USA.
To better characterize fluent and nonfluent variants of primary progressive aphasia (PPA). Although investigators have recognized both fluent and nonfluent patients with PPA, the clinical and neuroimaging features of these variants have not been fully defined. We present clinical and neuropsychological data on 47 PPA patients comparing the fluent (n=21) and nonfluent (n=26) subjects. We further compared language features with PET/SPECT data available on 39 of these patients. Compared to the nonfluent PPA patients, those with fluent PPA had greater impairment of confrontational naming and loss of single word comprehension. They also exhibited semantic paraphasic errors and loss of single word comprehension. Patients with nonfluent PPA were more likely to be female, were more often dysarthric, and exhibited phonological speech errors in the absence of semantic errors. No significant differences were seen with regard to left hemisphere abnormalities, suggesting that both variants result from mechanisms that overlap frontal, temporal, and parietal regions. Of the language measures, only semantic paraphasias were strongly localized, in this case to the left temporal lobe. Fluent and nonfluent forms of PPA are clinically distinguishable by letter fluency, single word comprehension, object naming, and types of paraphasic errors. Nevertheless, there is a large amount of overlap between dysfunctional anatomic regions associated with these syndromes.
PMID: 15896383 [PubMed - in process]
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Anthony H. Risser
neuroscience | neuropsychology | brain | aphasia | neuroimaging
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- What's New In ... Aphasia?
Here are references to some recent papers covering important topics in aphasia: Otsuki M, Soma Y, Yoshimura N, Miyashita K, Nagatsuka K, Naritomi H. How to improve repetition ability in patients with Wernicke's aphasia: The effect of a disguised task....
- Abstract Of The Day: Aphasia
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Neuroscience
Abstract of the Day: Primary Progressive Aphasia (PPA)
Clark DG, Charuvastra A, Miller BL, Shapira JS, Mendez MF. Fluent versus nonfluent primary progressive aphasia: A comparison of clinical and functional neuroimaging features. Brain and Language 2005 Jul; 94(1): 54-60.
David Geffen School of Medicine, Department of Neurology, University of California-Los Angeles, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., 3-South Neurobehavior Unit (116AF), Los Angeles, CA 90073, USA.
To better characterize fluent and nonfluent variants of primary progressive aphasia (PPA). Although investigators have recognized both fluent and nonfluent patients with PPA, the clinical and neuroimaging features of these variants have not been fully defined. We present clinical and neuropsychological data on 47 PPA patients comparing the fluent (n=21) and nonfluent (n=26) subjects. We further compared language features with PET/SPECT data available on 39 of these patients. Compared to the nonfluent PPA patients, those with fluent PPA had greater impairment of confrontational naming and loss of single word comprehension. They also exhibited semantic paraphasic errors and loss of single word comprehension. Patients with nonfluent PPA were more likely to be female, were more often dysarthric, and exhibited phonological speech errors in the absence of semantic errors. No significant differences were seen with regard to left hemisphere abnormalities, suggesting that both variants result from mechanisms that overlap frontal, temporal, and parietal regions. Of the language measures, only semantic paraphasias were strongly localized, in this case to the left temporal lobe. Fluent and nonfluent forms of PPA are clinically distinguishable by letter fluency, single word comprehension, object naming, and types of paraphasic errors. Nevertheless, there is a large amount of overlap between dysfunctional anatomic regions associated with these syndromes.
PMID: 15896383 [PubMed - in process]
-
Anthony H. Risser
neuroscience | neuropsychology | brain | aphasia | neuroimaging
- Neuropsychology Abstract Of The Day: Donepezil And Aphasia
Chen Y, Li YS, Wang ZY, Xu Q, Shi GW, & Lin Y. [The efficacy of donepezil for post-stroke aphasia: a pilot case control study.] Zhonghua Nei Ke Za Zhi. 2010 Feb, 49(2), 115-118. OBJECTIVE: To evaluate the efficacy of donepezil for post-stroke aphasia....
- Abstract Of The Day: Verbal Fluency Testing And Multiple Sclerosis (ms)
Henry JD, Beatty WW. Verbal fluency deficits in multiple sclerosis. Neuropsychologia. 2005 Nov 14; [Epub ahead of print] School of Psychology, University of New South Wales, Sydney, NSW, Australia. A quantitative review of 35 studies with 3673 participants...
- What's New In ... Aphasia?
Here are references to some recent papers covering important topics in aphasia: Otsuki M, Soma Y, Yoshimura N, Miyashita K, Nagatsuka K, Naritomi H. How to improve repetition ability in patients with Wernicke's aphasia: The effect of a disguised task....
- Abstract Of The Day: Aphasia
Saygin AP, Wilson SM, Dronkers NF, Bates E. Action comprehension in aphasia: Linguistic and non-linguistic deficits and their lesion correlates. Neuropsychologia. 2004; 42(13): 1788-804. Department of Cognitive Science, University of California,...
- A New Slant On Frontal Connectivity: The Frontal Aslant Tract
The frontal aslant tract is shown in yellow (Fig 5, Catani et al., 2012). It's not every day that you hear about a newly described white matter pathway in the human brain. An interesting new study by a group of researchers in London and Chicago found...